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Characterization and phylogenetic analysis of bovine gammaherpesvirus 4 isolated in China, 2022
Bovine gammaherpesvirus 4 (BoHV-4) is a common virus detected in bovine with respiratory disease worldwide. In this study, we identified and characterized a novel BoHV-4 strain, referred as HB-ZJK, in vaginal swabs collected from cattle in China, 2022. The long unique region (LUR) of HB-ZJK is 10,98...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9986666/ https://www.ncbi.nlm.nih.gov/pubmed/36877428 http://dx.doi.org/10.1007/s11262-023-01981-5 |
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author | Guo, Weiqiang Sun, Tong Liu, Yingnan Duan, Xulai Tian, Chuanwen Zhou, Zhou Jung, Yong-Sam Liu, Jingyi Chen, Hongjun |
author_facet | Guo, Weiqiang Sun, Tong Liu, Yingnan Duan, Xulai Tian, Chuanwen Zhou, Zhou Jung, Yong-Sam Liu, Jingyi Chen, Hongjun |
author_sort | Guo, Weiqiang |
collection | PubMed |
description | Bovine gammaherpesvirus 4 (BoHV-4) is a common virus detected in bovine with respiratory disease worldwide. In this study, we identified and characterized a novel BoHV-4 strain, referred as HB-ZJK, in vaginal swabs collected from cattle in China, 2022. The long unique region (LUR) of HB-ZJK is 10,9811 bp in length. It shares 99.17% to 99.38% nucleotide identity to five BoHV-4 strains available in GenBank and the highest similarity was seen with BoHV-4V. test (JN133502.1) strain (99.38%). Mutations, insertions or deletions were observed mainly in HB-ZJK gB (ORF8), TK (ORF21), gH (ORF22), MCP (ORF25), PK (ORF36), gM (ORF39), and gL (ORF47) genes compared to its genomic coordinates. Phylogenetic analyses of gB and TK genes showed that HB-ZJK clustered with China 512 (2019), B6010 (2009), and J4034 (2009) strains, demonstrating that the isolated HB-ZJK belongs to genotype 1. This is the first report that has revealed a comprehensive genome profile of BoHV-4 strain in China. This study will provide foundation for epidemiological investigations of BoHV-4 and contribute to the molecular and pathogenic studies of BoHV-4. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11262-023-01981-5. |
format | Online Article Text |
id | pubmed-9986666 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-99866662023-03-06 Characterization and phylogenetic analysis of bovine gammaherpesvirus 4 isolated in China, 2022 Guo, Weiqiang Sun, Tong Liu, Yingnan Duan, Xulai Tian, Chuanwen Zhou, Zhou Jung, Yong-Sam Liu, Jingyi Chen, Hongjun Virus Genes Original Paper Bovine gammaherpesvirus 4 (BoHV-4) is a common virus detected in bovine with respiratory disease worldwide. In this study, we identified and characterized a novel BoHV-4 strain, referred as HB-ZJK, in vaginal swabs collected from cattle in China, 2022. The long unique region (LUR) of HB-ZJK is 10,9811 bp in length. It shares 99.17% to 99.38% nucleotide identity to five BoHV-4 strains available in GenBank and the highest similarity was seen with BoHV-4V. test (JN133502.1) strain (99.38%). Mutations, insertions or deletions were observed mainly in HB-ZJK gB (ORF8), TK (ORF21), gH (ORF22), MCP (ORF25), PK (ORF36), gM (ORF39), and gL (ORF47) genes compared to its genomic coordinates. Phylogenetic analyses of gB and TK genes showed that HB-ZJK clustered with China 512 (2019), B6010 (2009), and J4034 (2009) strains, demonstrating that the isolated HB-ZJK belongs to genotype 1. This is the first report that has revealed a comprehensive genome profile of BoHV-4 strain in China. This study will provide foundation for epidemiological investigations of BoHV-4 and contribute to the molecular and pathogenic studies of BoHV-4. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11262-023-01981-5. Springer US 2023-03-06 2023 /pmc/articles/PMC9986666/ /pubmed/36877428 http://dx.doi.org/10.1007/s11262-023-01981-5 Text en © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Original Paper Guo, Weiqiang Sun, Tong Liu, Yingnan Duan, Xulai Tian, Chuanwen Zhou, Zhou Jung, Yong-Sam Liu, Jingyi Chen, Hongjun Characterization and phylogenetic analysis of bovine gammaherpesvirus 4 isolated in China, 2022 |
title | Characterization and phylogenetic analysis of bovine gammaherpesvirus 4 isolated in China, 2022 |
title_full | Characterization and phylogenetic analysis of bovine gammaherpesvirus 4 isolated in China, 2022 |
title_fullStr | Characterization and phylogenetic analysis of bovine gammaherpesvirus 4 isolated in China, 2022 |
title_full_unstemmed | Characterization and phylogenetic analysis of bovine gammaherpesvirus 4 isolated in China, 2022 |
title_short | Characterization and phylogenetic analysis of bovine gammaherpesvirus 4 isolated in China, 2022 |
title_sort | characterization and phylogenetic analysis of bovine gammaherpesvirus 4 isolated in china, 2022 |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9986666/ https://www.ncbi.nlm.nih.gov/pubmed/36877428 http://dx.doi.org/10.1007/s11262-023-01981-5 |
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