Incorporating Alternative Polygenic Risk Scores into the BOADICEA Breast Cancer Risk Prediction Model

BACKGROUND: The multifactorial risk prediction model BOADICEA enables identification of women at higher or lower risk of developing breast cancer. BOADICEA models genetic susceptibility in terms of the effects of rare variants in breast cancer susceptibility genes and a polygenic component, decompos...

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Detalles Bibliográficos
Autores principales: Mavaddat, Nasim, Ficorella, Lorenzo, Carver, Tim, Lee, Andrew, Cunningham, Alex P., Lush, Michael, Dennis, Joe, Tischkowitz, Marc, Downes, Kate, Hu, Donglei, Hahnen, Eric, Schmutzler, Rita K., Stockley, Tracy L., Downs, Gregory S., Zhang, Tong, Chiarelli, Anna M., Bojesen, Stig E., Liu, Cong, Chung, Wendy K., Pardo, Monica, Feliubadaló, Lidia, Balmaña, Judith, Simard, Jacques, Antoniou, Antonis C., Easton, Douglas F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9986688/
https://www.ncbi.nlm.nih.gov/pubmed/36649146
http://dx.doi.org/10.1158/1055-9965.EPI-22-0756

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