Cargando…

Discovery of a Missense Mutation (Q222K) of the APOE Gene from the Australian Imaging, Biomarker and Lifestyle Study

After age, polymorphisms of the Apolipoprotein E (APOE) gene are the biggest risk factor for the development of Alzheimer’s disease (AD). During our investigation to discovery biomarkers in plasma, using 2D gel electrophoresis, we found an individual with and unusual apoE isoelectric point compared...

Descripción completa

Detalles Bibliográficos
Autores principales:	Roberts, Blaine R., Laffoon, Scott B., Roberts, Anne M., Porter, Tenielle, Fowler, Chris, Masters, Colin L., Dratz, Edward A., Laws, Simon M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	IOS Press 2023
Materias:	Short Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9986708/ https://www.ncbi.nlm.nih.gov/pubmed/36891255 http://dx.doi.org/10.3233/ADR-220075

Ejemplares similares

Analysis of plasma proteins using 2D gels and novel fluorescent probes: in search of blood based biomarkers for Alzheimer’s disease
por: Laffoon, Scott B., et al.
Publicado: (2022)

Hair and salivary cortisol and their relationship with lifestyle, mood and cognitive outcomes in premanifest Huntington’s disease
por: Cruickshank, Travis, et al.
Publicado: (2021)

Standardization of Rn-222 at the Australian Radiation Laboratory
por: Gan, T. H., et al.
Publicado: (1990)

SPON1 Is Associated with Amyloid-β and APOE ε4-Related Cognitive Decline in Cognitively Normal Adults
por: Fernandez, Shane, et al.
Publicado: (2021)

KIBRA is associated with accelerated cognitive decline and hippocampal atrophy in APOE ε4-positive cognitively normal adults with high Aβ-amyloid burden
por: Porter, Tenielle, et al.
Publicado: (2018)

Utility of DNA Methylation as a Biomarker in Aging and Alzheimer’s Disease
por: Milicic, Lidija, et al.
Publicado: (2023)

COMT val158met is not associated with Aβ-amyloid and APOE ε4 related cognitive decline in cognitively normal older adults
por: Porter, Tenielle, et al.
Publicado: (2019)

Validation of a priori candidate Alzheimer’s disease SNPs with brain amyloid-beta deposition
por: Vacher, Michael, et al.
Publicado: (2019)

Sleep, Sirtuin 1 and Alzheimer’s disease: A review
por: Mehramiz, Mehrane, et al.
Publicado: (2022)

Mediterranean diet adherence and rate of cerebral Aβ-amyloid accumulation: Data from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing
por: Rainey-Smith, Stephanie R., et al.
Publicado: (2018)

Plasma apolipoprotein J as a potential biomarker for Alzheimer's disease: Australian Imaging, Biomarkers and Lifestyle study of aging
por: Gupta, Veer Bala, et al.
Publicado: (2015)

Relationship of Cognition and Alzheimer’s Disease with Gastrointestinal Tract Disorders: A Large-Scale Genetic Overlap and Mendelian Randomisation Analysis
por: Adewuyi, Emmanuel O., et al.
Publicado: (2022)

Follow-up plasma apolipoprotein E levels in the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing (AIBL) cohort
por: Gupta, Veer B, et al.
Publicado: (2015)

Current Insights on the Use of Insulin and the Potential Use of Insulin Mimetics in Targeting Insulin Signalling in Alzheimer’s Disease
por: Woodfield, Amy, et al.
Publicado: (2022)

A six-metabolite panel as potential blood-based biomarkers for Parkinson’s disease
por: Klatt, Stephan, et al.
Publicado: (2021)

A large-scale genome-wide cross-trait analysis reveals shared genetic architecture between Alzheimer’s disease and gastrointestinal tract disorders
por: Adewuyi, Emmanuel O., et al.
Publicado: (2022)

A Potential Role for Sirtuin-1 in Alzheimer’s Disease: Reviewing the Biological and Environmental Evidence
por: Mehramiz, Mehrane, et al.
Publicado: (2023)

Assessment of a polygenic hazard score for the onset of pre-clinical Alzheimer’s disease
por: Vacher, Michael, et al.
Publicado: (2022)

The Effects of Latrepirdine on Amyloid-β Aggregation and Toxicity
por: Porter, Tenielle, et al.
Publicado: (2016)

Discovery of radioactive decay of $^{222}$Ra and $^{224}$Ra by $^{14}$C emission
por: Price, P B, et al.
Publicado: (1985)

Common variants in MMP20 at 11q22.2 predispose to 11q deletion and neuroblastoma risk
por: Chang, Xiao, et al.
Publicado: (2017)

8q22.2q22.3 Microdeletion Syndrome Associated with Hearing Loss and Intractable Epilepsy
por: Rincon, Alejandra, et al.
Publicado: (2019)

Learning deficit in cognitively normal APOE ε4 carriers with LOW β‐amyloid
por: Lim, Yen Ying, et al.
Publicado: (2021)

Metalloproteomics: principles, challenges and applications to neurodegeneration
por: Lothian, Amber, et al.
Publicado: (2013)

Decreased Copper in Alzheimer's Disease Brain Is Predominantly in the Soluble Extractable Fraction
por: Rembach, Alan, et al.
Publicado: (2013)

LAMB3 Missense Variant in Australian Shepherd Dogs with Junctional Epidermolysis Bullosa
por: Kiener, Sarah, et al.
Publicado: (2020)

Amyloid-Related Memory Decline in Preclinical Alzheimer’s Disease Is Dependent on APOE ε4 and Is Detectable over 18-Months
por: Thai, Christine, et al.
Publicado: (2015)

Higher Coffee Consumption Is Associated With Slower Cognitive Decline and Less Cerebral Aβ-Amyloid Accumulation Over 126 Months: Data From the Australian Imaging, Biomarkers, and Lifestyle Study
por: Gardener, Samantha L., et al.
Publicado: (2021)

Comprehensive analysis of epigenetic clocks reveals associations between disproportionate biological ageing and hippocampal volume
por: Milicic, Lidija, et al.
Publicado: (2022)

Fifteen Years of the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study: Progress and Observations from 2,359 Older Adults Spanning the Spectrum from Cognitive Normality to Alzheimer’s Disease
por: Fowler, Christopher, et al.
Publicado: (2021)

Exploring discordant low amyloid beta and high neocortical tau positron emission tomography cases
por: Krishnadas, Natasha, et al.
Publicado: (2022)

Polygenic score modifies risk for Alzheimer's disease in APOE ε4 homozygotes at phenotypic extremes
por: Huq, Aamira J., et al.
Publicado: (2021)

KD4v: comprehensible knowledge discovery system for missense variant
por: Luu, Tien-Dao, et al.
Publicado: (2012)

Lamin A/C missense variants: from discovery to functional validation
por: Lazarte, Julieta, et al.
Publicado: (2021)

A Missense Mutation in Canine CLN6 in an Australian Shepherd with Neuronal Ceroid Lipofuscinosis
por: Katz, Martin L., et al.
Publicado: (2011)

Fetus of 8q22.2q24.3 duplication and 13q33.2q34 deletion derived from a maternal balanced translocation
por: Liu, Tong, et al.
Publicado: (2020)

An IL1RL1 genetic variant lowers soluble ST2 levels and the risk effects of APOE-ε4 in female patients with Alzheimer’s disease
por: Jiang, Yuanbing, et al.
Publicado: (2022)

Molecular Cytogenetic Characterization of an inv(Y)(p11.2q11.221∼q11.222) in a Syrian Family
por: Al-Achkar, W, et al.
Publicado: (2013)

Altered levels of blood proteins in Alzheimer's disease longitudinal study: Results from Australian Imaging Biomarkers Lifestyle Study of Ageing cohort
por: Gupta, Veer Bala, et al.
Publicado: (2017)

Effects of Sex, APOE4, and Lifestyle Activities on Cognitive Reserve in Older Adults
por: Pa, Judy, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_hj9i810oqiuli468aava8vend7