Creutzfeldt-Jakob Disease in a Patient with Previous COVID-19 Infection: “The Virus Caused the Derangement in My Brain”

Recent studies have speculated a link between Creutzfeldt-Jakob disease (CJD) and COVID-19, following the description of CJD cases after COVID-19 infection. We report the case of a 71-year-old female patient who developed neuropsychiatric and neurological symptoms after COVID-19 infection and was la...

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Autores principales: Leccese, Deborah, Cornacchini, Sara, Nacmias, Benedetta, Sorbi, Sandro, Bessi, Valentina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2023
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9986709/
https://www.ncbi.nlm.nih.gov/pubmed/36891254
http://dx.doi.org/10.3233/ADR-220095
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author Leccese, Deborah
Cornacchini, Sara
Nacmias, Benedetta
Sorbi, Sandro
Bessi, Valentina
author_facet Leccese, Deborah
Cornacchini, Sara
Nacmias, Benedetta
Sorbi, Sandro
Bessi, Valentina
author_sort Leccese, Deborah
collection PubMed
description Recent studies have speculated a link between Creutzfeldt-Jakob disease (CJD) and COVID-19, following the description of CJD cases after COVID-19 infection. We report the case of a 71-year-old female patient who developed neuropsychiatric and neurological symptoms after COVID-19 infection and was later diagnosed with CJD. Cerebrospinal fluid (CSF) total tau levels were slightly increased. She resulted prion protein gene (PRNP) M129V heterozygous. We aim to emphasize the role of the polymorphism at codon 129 of PRNP gene on the clinical phenotype and duration of CJD, and the CSF total tau levels that likely correlate with the rate of disease progression.
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spelling pubmed-99867092023-03-07 Creutzfeldt-Jakob Disease in a Patient with Previous COVID-19 Infection: “The Virus Caused the Derangement in My Brain” Leccese, Deborah Cornacchini, Sara Nacmias, Benedetta Sorbi, Sandro Bessi, Valentina J Alzheimers Dis Rep Short Communication Recent studies have speculated a link between Creutzfeldt-Jakob disease (CJD) and COVID-19, following the description of CJD cases after COVID-19 infection. We report the case of a 71-year-old female patient who developed neuropsychiatric and neurological symptoms after COVID-19 infection and was later diagnosed with CJD. Cerebrospinal fluid (CSF) total tau levels were slightly increased. She resulted prion protein gene (PRNP) M129V heterozygous. We aim to emphasize the role of the polymorphism at codon 129 of PRNP gene on the clinical phenotype and duration of CJD, and the CSF total tau levels that likely correlate with the rate of disease progression. IOS Press 2023-02-14 /pmc/articles/PMC9986709/ /pubmed/36891254 http://dx.doi.org/10.3233/ADR-220095 Text en © 2023 – The authors. Published by IOS Press https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Leccese, Deborah
Cornacchini, Sara
Nacmias, Benedetta
Sorbi, Sandro
Bessi, Valentina
Creutzfeldt-Jakob Disease in a Patient with Previous COVID-19 Infection: “The Virus Caused the Derangement in My Brain”
title Creutzfeldt-Jakob Disease in a Patient with Previous COVID-19 Infection: “The Virus Caused the Derangement in My Brain”
title_full Creutzfeldt-Jakob Disease in a Patient with Previous COVID-19 Infection: “The Virus Caused the Derangement in My Brain”
title_fullStr Creutzfeldt-Jakob Disease in a Patient with Previous COVID-19 Infection: “The Virus Caused the Derangement in My Brain”
title_full_unstemmed Creutzfeldt-Jakob Disease in a Patient with Previous COVID-19 Infection: “The Virus Caused the Derangement in My Brain”
title_short Creutzfeldt-Jakob Disease in a Patient with Previous COVID-19 Infection: “The Virus Caused the Derangement in My Brain”
title_sort creutzfeldt-jakob disease in a patient with previous covid-19 infection: “the virus caused the derangement in my brain”
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9986709/
https://www.ncbi.nlm.nih.gov/pubmed/36891254
http://dx.doi.org/10.3233/ADR-220095
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