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The relation between pericoronary fat thickness and density quantified by coronary computed tomography angiography with coronary artery disease severity

OBJECTIVE: To study the correlation between epicardial fat thickness (EFT), pericoronary fat thickness (PCFT), and pericoronary fat density (PCFD) with the existence and severity of coronary artery disease (CAD). METHODS: This cross-sectional study included 210 patients referred for multislice CT an...

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Autores principales: Farag, Shereen I., Mostafa, Shaimaa A., El-Rabbat, Khaled E., El-Kaffas, Sameh M., Awara, Dalia M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9986735/
https://www.ncbi.nlm.nih.gov/pubmed/36640839
http://dx.doi.org/10.1016/j.ihj.2023.01.006
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author Farag, Shereen I.
Mostafa, Shaimaa A.
El-Rabbat, Khaled E.
El-Kaffas, Sameh M.
Awara, Dalia M.
author_facet Farag, Shereen I.
Mostafa, Shaimaa A.
El-Rabbat, Khaled E.
El-Kaffas, Sameh M.
Awara, Dalia M.
author_sort Farag, Shereen I.
collection PubMed
description OBJECTIVE: To study the correlation between epicardial fat thickness (EFT), pericoronary fat thickness (PCFT), and pericoronary fat density (PCFD) with the existence and severity of coronary artery disease (CAD). METHODS: This cross-sectional study included 210 patients referred for multislice CT angiography. Group I normal CTCA, Group II patients had non-obstructive atherosclerosis, and Group III patients had obstructive atherosclerosis. All patients underwent a clinical examination, history taking, and multislice CT angiography. RESULTS: The mean EFT was significantly greater in group III (10.43 ± 2.31 mm) compared to groups II (6.30 ± 1.61 mm) and I (5.06 ± 1.14 mm). The mean PCFT was significantly greater in group III (17.96 ± 2.89 mm) compared to group II (11.47 ± 2.51 mm) and group I (9.67 ± 1.99 mm). PCFD was significantly higher adjacent to the lesion (−80.47 ± 29.14) compared to the normal segment (−109.03 ± 35.24), higher in the obstructive group (−59.44 ± 20.10) compared to the non-obstructive group (−101.51 ± 20.23), but lower in calcified lesions (−89.58 ± 28.94) compared to non-calcified (−75.01 ± 29.20), and mixed lesions (−74.83 ± 26.90). EFT and PCFT cut-off values for predicting obstructive CAD were 8.3 and 12.4 mm, respectively, with 87.1% and 92.9% sensitivity and 92.9% and 86.4% specificity, respectively. CONCLUSION: There is a significant association between epicardial fat thickness, pericoronary fat thickness and density with the severity of coronary artery disease.
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spelling pubmed-99867352023-03-07 The relation between pericoronary fat thickness and density quantified by coronary computed tomography angiography with coronary artery disease severity Farag, Shereen I. Mostafa, Shaimaa A. El-Rabbat, Khaled E. El-Kaffas, Sameh M. Awara, Dalia M. Indian Heart J Original Article OBJECTIVE: To study the correlation between epicardial fat thickness (EFT), pericoronary fat thickness (PCFT), and pericoronary fat density (PCFD) with the existence and severity of coronary artery disease (CAD). METHODS: This cross-sectional study included 210 patients referred for multislice CT angiography. Group I normal CTCA, Group II patients had non-obstructive atherosclerosis, and Group III patients had obstructive atherosclerosis. All patients underwent a clinical examination, history taking, and multislice CT angiography. RESULTS: The mean EFT was significantly greater in group III (10.43 ± 2.31 mm) compared to groups II (6.30 ± 1.61 mm) and I (5.06 ± 1.14 mm). The mean PCFT was significantly greater in group III (17.96 ± 2.89 mm) compared to group II (11.47 ± 2.51 mm) and group I (9.67 ± 1.99 mm). PCFD was significantly higher adjacent to the lesion (−80.47 ± 29.14) compared to the normal segment (−109.03 ± 35.24), higher in the obstructive group (−59.44 ± 20.10) compared to the non-obstructive group (−101.51 ± 20.23), but lower in calcified lesions (−89.58 ± 28.94) compared to non-calcified (−75.01 ± 29.20), and mixed lesions (−74.83 ± 26.90). EFT and PCFT cut-off values for predicting obstructive CAD were 8.3 and 12.4 mm, respectively, with 87.1% and 92.9% sensitivity and 92.9% and 86.4% specificity, respectively. CONCLUSION: There is a significant association between epicardial fat thickness, pericoronary fat thickness and density with the severity of coronary artery disease. Elsevier 2023 2023-01-11 /pmc/articles/PMC9986735/ /pubmed/36640839 http://dx.doi.org/10.1016/j.ihj.2023.01.006 Text en © 2023 Cardiological Society of India. Published by Elsevier, a division of RELX India, Pvt. Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Farag, Shereen I.
Mostafa, Shaimaa A.
El-Rabbat, Khaled E.
El-Kaffas, Sameh M.
Awara, Dalia M.
The relation between pericoronary fat thickness and density quantified by coronary computed tomography angiography with coronary artery disease severity
title The relation between pericoronary fat thickness and density quantified by coronary computed tomography angiography with coronary artery disease severity
title_full The relation between pericoronary fat thickness and density quantified by coronary computed tomography angiography with coronary artery disease severity
title_fullStr The relation between pericoronary fat thickness and density quantified by coronary computed tomography angiography with coronary artery disease severity
title_full_unstemmed The relation between pericoronary fat thickness and density quantified by coronary computed tomography angiography with coronary artery disease severity
title_short The relation between pericoronary fat thickness and density quantified by coronary computed tomography angiography with coronary artery disease severity
title_sort relation between pericoronary fat thickness and density quantified by coronary computed tomography angiography with coronary artery disease severity
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9986735/
https://www.ncbi.nlm.nih.gov/pubmed/36640839
http://dx.doi.org/10.1016/j.ihj.2023.01.006
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