Hacd2 deficiency in mice leads to an early and lethal mitochondrial disease

OBJECTIVE: Mitochondria fuel most animal cells with ATP, ensuring proper energetic metabolism of organs. Early and extensive mitochondrial dysfunction often leads to severe disorders through multiorgan failure. Hacd2 gene encodes an enzyme involved in very long chain fatty acid (C ≥ 18) synthesis, y...

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Detalles Bibliográficos
Autores principales: Khadhraoui, Nahed, Prola, Alexandre, Vandestienne, Aymeline, Blondelle, Jordan, Guillaud, Laurent, Courtin, Guillaume, Bodak, Maxime, Prost, Bastien, Huet, Hélène, Wintrebert, Mélody, Péchoux, Christine, Solgadi, Audrey, Relaix, Frédéric, Tiret, Laurent, Pilot-Storck, Fanny
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9986742/
https://www.ncbi.nlm.nih.gov/pubmed/36693621
http://dx.doi.org/10.1016/j.molmet.2023.101677

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