STING agonism turns human T cells into interferon‐producing cells but impedes their functionality

The cGAS‐STING (cyclic GMP‐AMP synthase‐stimulator of interferon genes) axis is the predominant DNA sensing system in cells of the innate immune system. However, human T cells also express high levels of STING, while its role and physiological trigger remain largely unknown. Here, we show that the c...

Descripción completa

Detalles Bibliográficos
Autores principales: Kuhl, Niklas, Linder, Andreas, Philipp, Nora, Nixdorf, Daniel, Fischer, Hannah, Veth, Simon, Kuut, Gunnar, Xu, Teng Teng, Theurich, Sebastian, Carell, Thomas, Subklewe, Marion, Hornung, Veit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9986811/
https://www.ncbi.nlm.nih.gov/pubmed/36705069
http://dx.doi.org/10.15252/embr.202255536

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9986811/
https://www.ncbi.nlm.nih.gov/pubmed/36705069
http://dx.doi.org/10.15252/embr.202255536

Ejemplares similares