Cargando…

Quantitative Seed Amplification Assay: A Proof-of-Principle Study

[Image: see text] Amyloid fibrils of the protein α-synuclein (αS) have recently been identified as a biomarker for Parkinson’s disease (PD). To detect the presence of these amyloid fibrils, seed amplification assays (SAAs) have been developed. SAAs allow for the detection of αS amyloid fibrils in bi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vaneyck, Jonathan, Yousif, Therese A., Segers-Nolten, Ine, Blum, Christian, Claessens, Mireille M.A.E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9986870/ https://www.ncbi.nlm.nih.gov/pubmed/36795058 http://dx.doi.org/10.1021/acs.jpcb.2c08326

Ejemplares similares

Cross-seeding of alpha-synuclein aggregation by amyloid fibrils of food proteins
por: Vaneyck, Jonathan, et al.
Publicado: (2021)

Different Conformational Subensembles of the Intrinsically Disordered Protein α-Synuclein in Cells
por: Fakhree, Mohammad A. A., et al.
Publicado: (2018)

Interactions between SARS-CoV-2 N-Protein and α-Synuclein Accelerate Amyloid Formation
por: Semerdzhiev, Slav A., et al.
Publicado: (2021)

Parkinson’s Protein α-Synuclein Binds Efficiently and with a Novel Conformation to Two Natural Membrane Mimics
por: Kumar, Pravin, et al.
Publicado: (2015)

Protein Adsorption Enhances Energy Dissipation in Networks of Lysozyme Amyloid Fibrils
por: van Dalen, Maurice C. E., et al.
Publicado: (2021)

The Future of Seed Amplification Assays and Clinical Trials
por: Coysh, Thomas, et al.
Publicado: (2022)

Rapid quantitative pharmacodynamic imaging by a novel method: theory, simulation testing and proof of principle
por: Black, Kevin J., et al.
Publicado: (2013)

Endovascular baroreflex amplification and the effect on sympathetic nerve activity in patients with resistant hypertension: A proof-of-principle study
por: van Kleef, Monique E. A. M., et al.
Publicado: (2021)

Central and peripheral α‐synuclein in Parkinson disease detected by seed amplification assay
por: Chahine, Lana M., et al.
Publicado: (2023)

Highly Rapid Amplification-Free and Quantitative DNA Imaging Assay
por: Klamp, Tobias, et al.
Publicado: (2013)

Development of Quantitative Rapid Isothermal Amplification Assay for Leishmania donovani
por: Khan, Md Anik Ashfaq, et al.
Publicado: (2021)

Gamma Factory Proof-of-Principle Experiment
por: Krasny, M W, et al.
Publicado: (2019)

Exogenous α-synuclein hinders synaptic communication in cultured cortical primary rat neurons
por: Hassink, G. C., et al.
Publicado: (2018)

In vitro aggregating β-lactamase-polyQ chimeras do not induce toxic effects in an in vivo Caenorhabditis elegans model
por: Van Assche, Roel, et al.
Publicado: (2017)

Seed Amplification Assay to Diagnose Early Parkinson's and Predict Dopaminergic Deficit Progression
por: Concha‐Marambio, Luis, et al.
Publicado: (2021)

Approaching the Gut and Nasal Microbiota in Parkinson’s Disease in the Era of the Seed Amplification Assays
por: Consonni, Alessandra, et al.
Publicado: (2022)

Seed Amplification Assay as a Diagnostic Tool in Newly-Diagnosed Parkinson’s Disease
por: Oftedal, Linn, et al.
Publicado: (2023)

Tau seed amplification assay reveals relationship between seeding and pathological forms of tau in Alzheimer’s disease brain
por: Frey, Bryan, et al.
Publicado: (2023)

Antiangiogenesis in recurrent glioblastoma: proof of principle
por: Nossek, Erez, et al.
Publicado: (2009)

An in vitro proof-of-principle study of sonobactericide
por: Lattwein, Kirby R., et al.
Publicado: (2018)

Proof of principle for epitope-focused vaccine design
por: Correia, Bruno E., et al.
Publicado: (2014)

Proof of principle of G-APD based hybrid photodetectors
por: Joram, C, et al.
Publicado: (2010)

Time-of-flight computed tomography - proof of principle
por: Rossignol, J, et al.
Publicado: (2020)

Technical aspects, R&D and Proof-of-Principle
por: Dutheil, Yann
Publicado: (2020)

Mohs surgery: proclamation, proof, principles, and promise
por: Bartley, George B
Publicado: (2004)

Proof-of-principle: targeted childhood leukemia prevention
por: Cobaleda, César, et al.
Publicado: (2023)

The development of standard samples with a defined number of antigen-specific T cells to harmonize T cell assays: a proof-of-principle study
por: Singh, Satwinder Kaur, et al.
Publicado: (2012)

Combining skin and olfactory α-synuclein seed amplification assays (SAA)—towards biomarker-driven phenotyping in synucleinopathies
por: Kuzkina, A., et al.
Publicado: (2023)

A proof-of-concept assay for quantitative and optical assessment of drug-induced toxicity in renal organoids
por: Dilz, Jasmin, et al.
Publicado: (2023)

Proof-of-principle experiments of laser wake-field acceleration
por: Nakajima, K, et al.
Publicado: (1995)

Principles of seed pathology
por: Agarwal, Vijendra K.
Publicado: (1987)

Concentrating Aggregation-Induced Fluorescence in Planar Waveguides: A Proof-of-Principle
por: Banal, James L., et al.
Publicado: (2014)

Exploring Intra- and Inter-Regional Interactions in the IDP α-Synuclein Using smFRET and MD Simulations
por: Heesink, Gobert, et al.
Publicado: (2023)

A semi-automatic seed point-based method for separation of individual vertebrae in 3D surface meshes: a proof of principle study
por: Pijpker, Peter A. J., et al.
Publicado: (2021)

High diagnostic performance of independent alpha-synuclein seed amplification assays for detection of early Parkinson’s disease
por: Russo, Marco J., et al.
Publicado: (2021)

Seed amplification assay of nasal swab extracts for accurate and non-invasive molecular diagnosis of neurodegenerative diseases
por: Duan, Suying, et al.
Publicado: (2023)

Cerebrospinal fluid lipoproteins inhibit α-synuclein aggregation by interacting with oligomeric species in seed amplification assays
por: Bellomo, Giovanni, et al.
Publicado: (2023)

Seed amplification assay results illustrate discrepancy in Parkinson’s disease clinical diagnostic accuracy and error rates
por: Middleton, John Stephen, et al.
Publicado: (2023)

Comparison between coagulation factor VIII quantified with one‐stage activity assay and with mass spectrometry in haemophilia A patients: Proof of principle
por: Donners, Anouk A. M. T., et al.
Publicado: (2020)

An enhanced isothermal amplification assay for viral detection
por: Qian, Jason, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_tcumkmmutot0naleoe0nrq19be