Cargando…

A case of epidermal growth factor receptor tyrosine kinase inhibitor effectiveness in epidermal growth factor receptor mutation-positive squamous cell carcinoma

A 71-year-old non-smoker woman was admitted to our hospital because of left front chest pain. A computed tomography scan showed a large mass of >7.0 cm in the lower left part of the lung and multiple organ metastases in the liver, brain, bone, and left adrenal gland. Pathological analysis of a re...

Descripción completa

Detalles Bibliográficos
Autores principales: Matsumura, Sosuke, Ano, Satoshi, Kikuchi, Norihiro, Masuda, Michiko, Osawa, Hajime, Kondo, Yuzuru, Ishii, Yukio, Hizawa, Nobuyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9986888/
https://www.ncbi.nlm.nih.gov/pubmed/36890803
http://dx.doi.org/10.1177/2050313X231159504
_version_ 1784901264827482112
author Matsumura, Sosuke
Ano, Satoshi
Kikuchi, Norihiro
Masuda, Michiko
Osawa, Hajime
Kondo, Yuzuru
Ishii, Yukio
Hizawa, Nobuyuki
author_facet Matsumura, Sosuke
Ano, Satoshi
Kikuchi, Norihiro
Masuda, Michiko
Osawa, Hajime
Kondo, Yuzuru
Ishii, Yukio
Hizawa, Nobuyuki
author_sort Matsumura, Sosuke
collection PubMed
description A 71-year-old non-smoker woman was admitted to our hospital because of left front chest pain. A computed tomography scan showed a large mass of >7.0 cm in the lower left part of the lung and multiple organ metastases in the liver, brain, bone, and left adrenal gland. Pathological analysis of a resected specimen obtained by bronchoscopy revealed keratinization. In addition, p40 was positive and thyroid transcription factor-1, synaptophysin, CD56, and chromogranin A were negative by immunohistochemistry. Programmed cell death ligand 1 expression was 1%–10%, and exon 19 deletion was detected. We diagnosed the patient with stage IVB lung squamous cell carcinoma and administered osimertinib. Osimertinib was later replaced with afatinib because of grade 3 skin rash. Overall, the size of the cancer was decreased. Furthermore, her symptoms, laboratory data, and computer tomographic findings markedly improved. In summary, we experienced a case of epidermal growth factor receptor–positive lung squamous cell carcinoma that was responsive to epidermal growth factor receptor tyrosine kinase inhibitors.
format Online
Article
Text
id pubmed-9986888
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher SAGE Publications
record_format MEDLINE/PubMed
spelling pubmed-99868882023-03-07 A case of epidermal growth factor receptor tyrosine kinase inhibitor effectiveness in epidermal growth factor receptor mutation-positive squamous cell carcinoma Matsumura, Sosuke Ano, Satoshi Kikuchi, Norihiro Masuda, Michiko Osawa, Hajime Kondo, Yuzuru Ishii, Yukio Hizawa, Nobuyuki SAGE Open Med Case Rep Case Report A 71-year-old non-smoker woman was admitted to our hospital because of left front chest pain. A computed tomography scan showed a large mass of >7.0 cm in the lower left part of the lung and multiple organ metastases in the liver, brain, bone, and left adrenal gland. Pathological analysis of a resected specimen obtained by bronchoscopy revealed keratinization. In addition, p40 was positive and thyroid transcription factor-1, synaptophysin, CD56, and chromogranin A were negative by immunohistochemistry. Programmed cell death ligand 1 expression was 1%–10%, and exon 19 deletion was detected. We diagnosed the patient with stage IVB lung squamous cell carcinoma and administered osimertinib. Osimertinib was later replaced with afatinib because of grade 3 skin rash. Overall, the size of the cancer was decreased. Furthermore, her symptoms, laboratory data, and computer tomographic findings markedly improved. In summary, we experienced a case of epidermal growth factor receptor–positive lung squamous cell carcinoma that was responsive to epidermal growth factor receptor tyrosine kinase inhibitors. SAGE Publications 2023-02-28 /pmc/articles/PMC9986888/ /pubmed/36890803 http://dx.doi.org/10.1177/2050313X231159504 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Report
Matsumura, Sosuke
Ano, Satoshi
Kikuchi, Norihiro
Masuda, Michiko
Osawa, Hajime
Kondo, Yuzuru
Ishii, Yukio
Hizawa, Nobuyuki
A case of epidermal growth factor receptor tyrosine kinase inhibitor effectiveness in epidermal growth factor receptor mutation-positive squamous cell carcinoma
title A case of epidermal growth factor receptor tyrosine kinase inhibitor effectiveness in epidermal growth factor receptor mutation-positive squamous cell carcinoma
title_full A case of epidermal growth factor receptor tyrosine kinase inhibitor effectiveness in epidermal growth factor receptor mutation-positive squamous cell carcinoma
title_fullStr A case of epidermal growth factor receptor tyrosine kinase inhibitor effectiveness in epidermal growth factor receptor mutation-positive squamous cell carcinoma
title_full_unstemmed A case of epidermal growth factor receptor tyrosine kinase inhibitor effectiveness in epidermal growth factor receptor mutation-positive squamous cell carcinoma
title_short A case of epidermal growth factor receptor tyrosine kinase inhibitor effectiveness in epidermal growth factor receptor mutation-positive squamous cell carcinoma
title_sort case of epidermal growth factor receptor tyrosine kinase inhibitor effectiveness in epidermal growth factor receptor mutation-positive squamous cell carcinoma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9986888/
https://www.ncbi.nlm.nih.gov/pubmed/36890803
http://dx.doi.org/10.1177/2050313X231159504
work_keys_str_mv AT matsumurasosuke acaseofepidermalgrowthfactorreceptortyrosinekinaseinhibitoreffectivenessinepidermalgrowthfactorreceptormutationpositivesquamouscellcarcinoma
AT anosatoshi acaseofepidermalgrowthfactorreceptortyrosinekinaseinhibitoreffectivenessinepidermalgrowthfactorreceptormutationpositivesquamouscellcarcinoma
AT kikuchinorihiro acaseofepidermalgrowthfactorreceptortyrosinekinaseinhibitoreffectivenessinepidermalgrowthfactorreceptormutationpositivesquamouscellcarcinoma
AT masudamichiko acaseofepidermalgrowthfactorreceptortyrosinekinaseinhibitoreffectivenessinepidermalgrowthfactorreceptormutationpositivesquamouscellcarcinoma
AT osawahajime acaseofepidermalgrowthfactorreceptortyrosinekinaseinhibitoreffectivenessinepidermalgrowthfactorreceptormutationpositivesquamouscellcarcinoma
AT kondoyuzuru acaseofepidermalgrowthfactorreceptortyrosinekinaseinhibitoreffectivenessinepidermalgrowthfactorreceptormutationpositivesquamouscellcarcinoma
AT ishiiyukio acaseofepidermalgrowthfactorreceptortyrosinekinaseinhibitoreffectivenessinepidermalgrowthfactorreceptormutationpositivesquamouscellcarcinoma
AT hizawanobuyuki acaseofepidermalgrowthfactorreceptortyrosinekinaseinhibitoreffectivenessinepidermalgrowthfactorreceptormutationpositivesquamouscellcarcinoma
AT matsumurasosuke caseofepidermalgrowthfactorreceptortyrosinekinaseinhibitoreffectivenessinepidermalgrowthfactorreceptormutationpositivesquamouscellcarcinoma
AT anosatoshi caseofepidermalgrowthfactorreceptortyrosinekinaseinhibitoreffectivenessinepidermalgrowthfactorreceptormutationpositivesquamouscellcarcinoma
AT kikuchinorihiro caseofepidermalgrowthfactorreceptortyrosinekinaseinhibitoreffectivenessinepidermalgrowthfactorreceptormutationpositivesquamouscellcarcinoma
AT masudamichiko caseofepidermalgrowthfactorreceptortyrosinekinaseinhibitoreffectivenessinepidermalgrowthfactorreceptormutationpositivesquamouscellcarcinoma
AT osawahajime caseofepidermalgrowthfactorreceptortyrosinekinaseinhibitoreffectivenessinepidermalgrowthfactorreceptormutationpositivesquamouscellcarcinoma
AT kondoyuzuru caseofepidermalgrowthfactorreceptortyrosinekinaseinhibitoreffectivenessinepidermalgrowthfactorreceptormutationpositivesquamouscellcarcinoma
AT ishiiyukio caseofepidermalgrowthfactorreceptortyrosinekinaseinhibitoreffectivenessinepidermalgrowthfactorreceptormutationpositivesquamouscellcarcinoma
AT hizawanobuyuki caseofepidermalgrowthfactorreceptortyrosinekinaseinhibitoreffectivenessinepidermalgrowthfactorreceptormutationpositivesquamouscellcarcinoma