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Improving the production of the micafungin precursor FR901379 in an industrial production strain

BACKGROUND: Micafungin is an echinocandin-type antifungal agent used for the clinical treatment of invasive fungal infections. It is semisynthesized from the sulfonated lipohexapeptide FR901379, a nonribosomal peptide produced by the filamentous fungus Coleophoma empetri. However, the low fermentati...

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Detalles Bibliográficos
Autores principales:	Men, Ping, Zhou, Yu, Xie, Li, Zhang, Xuan, Zhang, Wei, Huang, Xuenian, Lu, Xuefeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9987125/ https://www.ncbi.nlm.nih.gov/pubmed/36879280 http://dx.doi.org/10.1186/s12934-023-02050-0

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