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Asthma occurrence in children and early life systemic antibiotic use: an incidence density study

BACKGROUND: Results of studies evaluating the relationship between asthma occurrence and early life antibiotic use have been conflicting. The aim of this study was to investigate the relationship between occurrence of asthma in children and systemic antibiotic use in the first year of life based on...

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Autores principales: Bentouhami, Hayat, Bungwa, Milcah Kahkelam, Casas, Lidia, Coenen, Samuel, Weyler, Joost
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9987135/
https://www.ncbi.nlm.nih.gov/pubmed/36879341
http://dx.doi.org/10.1186/s13223-023-00773-8
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author Bentouhami, Hayat
Bungwa, Milcah Kahkelam
Casas, Lidia
Coenen, Samuel
Weyler, Joost
author_facet Bentouhami, Hayat
Bungwa, Milcah Kahkelam
Casas, Lidia
Coenen, Samuel
Weyler, Joost
author_sort Bentouhami, Hayat
collection PubMed
description BACKGROUND: Results of studies evaluating the relationship between asthma occurrence and early life antibiotic use have been conflicting. The aim of this study was to investigate the relationship between occurrence of asthma in children and systemic antibiotic use in the first year of life based on an incidence density study with careful consideration of the temporal aspects of the determinant-outcome relationship. METHODS: We conducted an incidence density study nested in a data collection project with information on 1128 mother–child pairs. Systemic antibiotic use in the first year of life was defined as excessive (≥ 4 courses) vs. non-excessive (< 4 courses) use based on information from weekly diaries. Events (cases) were defined as the first parent-reported occurrence of asthma in a child between 1 and 10 years of age. Population time ‘at risk’ was probed by sampling population moments (controls). Missing data were imputed. Multiple logistic regression was used to assess the association between current first asthma occurrence (incidence density) and systemic antibiotic use in the first year of life, to evaluate effect modification and adjust for confounding. RESULTS: Forty-seven first asthma events and 147 population moments were included. Excessive systemic antibiotic use in the first year of life showed more than twice the incidence density of asthma compared to non-excessive use (adjusted IDR [95% CI]: 2.18 [0.98, 4.87], p = 0.06). The association was more pronounced in children who have had lower respiratory tract infections (LRTIs) in the first year of life compared to children who had no LRTIs in the first year of life (adjusted IDR [95% CI]: 5.17 [1.19, 22.52] versus 1.49 [0.54, 4.14]). CONCLUSIONS: Excessive use of systemic antibiotics in the first year of life may play a role in the genesis of asthma in children. This effect is modified by the occurrence of LRTIs in the first year of life, with a stronger association observed in children experiencing LRTIs in the first year of life. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13223-023-00773-8.
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spelling pubmed-99871352023-03-07 Asthma occurrence in children and early life systemic antibiotic use: an incidence density study Bentouhami, Hayat Bungwa, Milcah Kahkelam Casas, Lidia Coenen, Samuel Weyler, Joost Allergy Asthma Clin Immunol Research BACKGROUND: Results of studies evaluating the relationship between asthma occurrence and early life antibiotic use have been conflicting. The aim of this study was to investigate the relationship between occurrence of asthma in children and systemic antibiotic use in the first year of life based on an incidence density study with careful consideration of the temporal aspects of the determinant-outcome relationship. METHODS: We conducted an incidence density study nested in a data collection project with information on 1128 mother–child pairs. Systemic antibiotic use in the first year of life was defined as excessive (≥ 4 courses) vs. non-excessive (< 4 courses) use based on information from weekly diaries. Events (cases) were defined as the first parent-reported occurrence of asthma in a child between 1 and 10 years of age. Population time ‘at risk’ was probed by sampling population moments (controls). Missing data were imputed. Multiple logistic regression was used to assess the association between current first asthma occurrence (incidence density) and systemic antibiotic use in the first year of life, to evaluate effect modification and adjust for confounding. RESULTS: Forty-seven first asthma events and 147 population moments were included. Excessive systemic antibiotic use in the first year of life showed more than twice the incidence density of asthma compared to non-excessive use (adjusted IDR [95% CI]: 2.18 [0.98, 4.87], p = 0.06). The association was more pronounced in children who have had lower respiratory tract infections (LRTIs) in the first year of life compared to children who had no LRTIs in the first year of life (adjusted IDR [95% CI]: 5.17 [1.19, 22.52] versus 1.49 [0.54, 4.14]). CONCLUSIONS: Excessive use of systemic antibiotics in the first year of life may play a role in the genesis of asthma in children. This effect is modified by the occurrence of LRTIs in the first year of life, with a stronger association observed in children experiencing LRTIs in the first year of life. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13223-023-00773-8. BioMed Central 2023-03-06 /pmc/articles/PMC9987135/ /pubmed/36879341 http://dx.doi.org/10.1186/s13223-023-00773-8 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Bentouhami, Hayat
Bungwa, Milcah Kahkelam
Casas, Lidia
Coenen, Samuel
Weyler, Joost
Asthma occurrence in children and early life systemic antibiotic use: an incidence density study
title Asthma occurrence in children and early life systemic antibiotic use: an incidence density study
title_full Asthma occurrence in children and early life systemic antibiotic use: an incidence density study
title_fullStr Asthma occurrence in children and early life systemic antibiotic use: an incidence density study
title_full_unstemmed Asthma occurrence in children and early life systemic antibiotic use: an incidence density study
title_short Asthma occurrence in children and early life systemic antibiotic use: an incidence density study
title_sort asthma occurrence in children and early life systemic antibiotic use: an incidence density study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9987135/
https://www.ncbi.nlm.nih.gov/pubmed/36879341
http://dx.doi.org/10.1186/s13223-023-00773-8
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