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Evaluación de desempeño del servicio de dosificación de precisión para vancomicina en un hospital pediátrico de nivel terciario
BACKGROUND: Plasma level-based therapeutic drug monitoring of vancomycin is recommended in the treatment of complex pediatric infections in order to increase the probability of achieving safe and effective pharmacotherapy. OBJECTIVE: To retrospectively evaluate the activities and performance of phar...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Universidad Nacional de Córdoba
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9987315/ https://www.ncbi.nlm.nih.gov/pubmed/36542578 http://dx.doi.org/10.31053/1853.0605.v79.n4.37726 |
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author | Caceres Guido, Paulo Licciardone, Nieves Riva, Natalia Pájaro González, Yina Echeverry Martínez, Jhon Jairo Taboada, Guillermo Federico Pagano, Eleonora Schaiquevich, Paula |
author_facet | Caceres Guido, Paulo Licciardone, Nieves Riva, Natalia Pájaro González, Yina Echeverry Martínez, Jhon Jairo Taboada, Guillermo Federico Pagano, Eleonora Schaiquevich, Paula |
author_sort | Caceres Guido, Paulo |
collection | PubMed |
description | BACKGROUND: Plasma level-based therapeutic drug monitoring of vancomycin is recommended in the treatment of complex pediatric infections in order to increase the probability of achieving safe and effective pharmacotherapy. OBJECTIVE: To retrospectively evaluate the activities and performance of pharmacotherapeutic optimization based on vancomycin levels at a tertiary pediatric hospital between 2007 and 2020. METHODS: Vancomycin levels of pediatric patients were analyzed, assessing care quality indicators and analytical verifications, as well as aspects related to teaching and research. The predictive performance of vancomycin levels was evaluated after adjustment of the therapeutic regimen using a population pharmacokinetic optimization program (BestDose v1.126) considering the coefficient of determination (R2), the mean absolute percentage error (MAPE), and the root mean square error (RMSE). RESULTS: 13269 vancomycin level determinations were analyzed; 70% were trough levels and 81% belonged to patients in the intensive care units. Forty percent of the trough levels were within the therapeutic range when adjusted without software. Three hundred seventy-four pharmacotherapeutic interventions, of which 97% were accepted by the treating physician; 75% of the post-adjustment trough levels were within the therapeutic range, compared to 40% when the approach was empirical, a difference that was statistically significant (p=0.03). The values associated with predictive performance (n subgroup of patients = 91) were: R2=0.61, MAPE=28.16%, and RMSE=3.3, which all showed to be adequate. CONCLUSION: The performance of therapeutic vancomycin monitoring and related pharmacokinetic clinical activities showed to be good. |
format | Online Article Text |
id | pubmed-9987315 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Universidad Nacional de Córdoba |
record_format | MEDLINE/PubMed |
spelling | pubmed-99873152023-03-07 Evaluación de desempeño del servicio de dosificación de precisión para vancomicina en un hospital pediátrico de nivel terciario Caceres Guido, Paulo Licciardone, Nieves Riva, Natalia Pájaro González, Yina Echeverry Martínez, Jhon Jairo Taboada, Guillermo Federico Pagano, Eleonora Schaiquevich, Paula Rev Fac Cien Med Univ Nac Cordoba Artículos Originales BACKGROUND: Plasma level-based therapeutic drug monitoring of vancomycin is recommended in the treatment of complex pediatric infections in order to increase the probability of achieving safe and effective pharmacotherapy. OBJECTIVE: To retrospectively evaluate the activities and performance of pharmacotherapeutic optimization based on vancomycin levels at a tertiary pediatric hospital between 2007 and 2020. METHODS: Vancomycin levels of pediatric patients were analyzed, assessing care quality indicators and analytical verifications, as well as aspects related to teaching and research. The predictive performance of vancomycin levels was evaluated after adjustment of the therapeutic regimen using a population pharmacokinetic optimization program (BestDose v1.126) considering the coefficient of determination (R2), the mean absolute percentage error (MAPE), and the root mean square error (RMSE). RESULTS: 13269 vancomycin level determinations were analyzed; 70% were trough levels and 81% belonged to patients in the intensive care units. Forty percent of the trough levels were within the therapeutic range when adjusted without software. Three hundred seventy-four pharmacotherapeutic interventions, of which 97% were accepted by the treating physician; 75% of the post-adjustment trough levels were within the therapeutic range, compared to 40% when the approach was empirical, a difference that was statistically significant (p=0.03). The values associated with predictive performance (n subgroup of patients = 91) were: R2=0.61, MAPE=28.16%, and RMSE=3.3, which all showed to be adequate. CONCLUSION: The performance of therapeutic vancomycin monitoring and related pharmacokinetic clinical activities showed to be good. Universidad Nacional de Córdoba 2022-12-21 /pmc/articles/PMC9987315/ /pubmed/36542578 http://dx.doi.org/10.31053/1853.0605.v79.n4.37726 Text en https://creativecommons.org/licenses/by-nc/4.0/Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial 4.0. |
spellingShingle | Artículos Originales Caceres Guido, Paulo Licciardone, Nieves Riva, Natalia Pájaro González, Yina Echeverry Martínez, Jhon Jairo Taboada, Guillermo Federico Pagano, Eleonora Schaiquevich, Paula Evaluación de desempeño del servicio de dosificación de precisión para vancomicina en un hospital pediátrico de nivel terciario |
title | Evaluación de desempeño del servicio de dosificación de precisión para vancomicina en un hospital pediátrico de nivel terciario |
title_full | Evaluación de desempeño del servicio de dosificación de precisión para vancomicina en un hospital pediátrico de nivel terciario |
title_fullStr | Evaluación de desempeño del servicio de dosificación de precisión para vancomicina en un hospital pediátrico de nivel terciario |
title_full_unstemmed | Evaluación de desempeño del servicio de dosificación de precisión para vancomicina en un hospital pediátrico de nivel terciario |
title_short | Evaluación de desempeño del servicio de dosificación de precisión para vancomicina en un hospital pediátrico de nivel terciario |
title_sort | evaluación de desempeño del servicio de dosificación de precisión para vancomicina en un hospital pediátrico de nivel terciario |
topic | Artículos Originales |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9987315/ https://www.ncbi.nlm.nih.gov/pubmed/36542578 http://dx.doi.org/10.31053/1853.0605.v79.n4.37726 |
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