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Relative changes in the cochlear summating potentials to paired-clicks predict speech-in-noise perception and subjective hearing acuity

Objective assays of human cochlear synaptopathy (CS) have been challenging to develop. It is suspected that relative summating potential (SP) changes are different in listeners with CS. In this proof-of-concept study, young, normal-hearing adults were recruited and assigned to a low/high-risk group...

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Autores principales: Lai, Jesyin, Bidelman, Gavin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9987329/
https://www.ncbi.nlm.nih.gov/pubmed/36319209
http://dx.doi.org/10.1121/10.0014815
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author Lai, Jesyin
Bidelman, Gavin M.
author_facet Lai, Jesyin
Bidelman, Gavin M.
author_sort Lai, Jesyin
collection PubMed
description Objective assays of human cochlear synaptopathy (CS) have been challenging to develop. It is suspected that relative summating potential (SP) changes are different in listeners with CS. In this proof-of-concept study, young, normal-hearing adults were recruited and assigned to a low/high-risk group for having CS based on their extended audiograms (9–16 kHz). SPs to paired-clicks with varying inter-click intervals isolated non-refractory receptor components of cochlear activity. Abrupt increases in SPs to paired- vs single-clicks were observed in high-risk listeners. Critically, exaggerated SPs predicted speech-in-noise and subjective hearing abilities, suggesting relative SP changes to rapid clicks might help identify putative synaptopathic listeners.
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spelling pubmed-99873292023-10-01 Relative changes in the cochlear summating potentials to paired-clicks predict speech-in-noise perception and subjective hearing acuity Lai, Jesyin Bidelman, Gavin M. JASA Express Lett Article Objective assays of human cochlear synaptopathy (CS) have been challenging to develop. It is suspected that relative summating potential (SP) changes are different in listeners with CS. In this proof-of-concept study, young, normal-hearing adults were recruited and assigned to a low/high-risk group for having CS based on their extended audiograms (9–16 kHz). SPs to paired-clicks with varying inter-click intervals isolated non-refractory receptor components of cochlear activity. Abrupt increases in SPs to paired- vs single-clicks were observed in high-risk listeners. Critically, exaggerated SPs predicted speech-in-noise and subjective hearing abilities, suggesting relative SP changes to rapid clicks might help identify putative synaptopathic listeners. 2022-10 /pmc/articles/PMC9987329/ /pubmed/36319209 http://dx.doi.org/10.1121/10.0014815 Text en https://creativecommons.org/licenses/by/4.0/All article content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Lai, Jesyin
Bidelman, Gavin M.
Relative changes in the cochlear summating potentials to paired-clicks predict speech-in-noise perception and subjective hearing acuity
title Relative changes in the cochlear summating potentials to paired-clicks predict speech-in-noise perception and subjective hearing acuity
title_full Relative changes in the cochlear summating potentials to paired-clicks predict speech-in-noise perception and subjective hearing acuity
title_fullStr Relative changes in the cochlear summating potentials to paired-clicks predict speech-in-noise perception and subjective hearing acuity
title_full_unstemmed Relative changes in the cochlear summating potentials to paired-clicks predict speech-in-noise perception and subjective hearing acuity
title_short Relative changes in the cochlear summating potentials to paired-clicks predict speech-in-noise perception and subjective hearing acuity
title_sort relative changes in the cochlear summating potentials to paired-clicks predict speech-in-noise perception and subjective hearing acuity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9987329/
https://www.ncbi.nlm.nih.gov/pubmed/36319209
http://dx.doi.org/10.1121/10.0014815
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