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Post COVID-19 Guillain–Barre syndrome presents as sensory dominant neuropathy with reversible conduction failure

Guillain–Barré syndrome (GBS) has several clinical variants. The sensory presentations of GBS are atypical but well-recognized. We report a patient who presented with predominantly sensory symptoms associated with reversible conduction failure (RCF). RCF is a well-defined neurophysiological abnormal...

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Autores principales: AlTahan, Abdulrahman M., AlAnazi, Mohammed H., AlTahan, Faisal A., AlAbandi, Fatima A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Riyadh : Armed Forces Hospital 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9987631/
https://www.ncbi.nlm.nih.gov/pubmed/36617454
http://dx.doi.org/10.17712/nsj.2023.1.20220057
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author AlTahan, Abdulrahman M.
AlAnazi, Mohammed H.
AlTahan, Faisal A.
AlAbandi, Fatima A.
author_facet AlTahan, Abdulrahman M.
AlAnazi, Mohammed H.
AlTahan, Faisal A.
AlAbandi, Fatima A.
author_sort AlTahan, Abdulrahman M.
collection PubMed
description Guillain–Barré syndrome (GBS) has several clinical variants. The sensory presentations of GBS are atypical but well-recognized. We report a patient who presented with predominantly sensory symptoms associated with reversible conduction failure (RCF). RCF is a well-defined neurophysiological abnormality noted mainly in axonal GBS and may be misinterpreted as evidence of demyelination. A 25-year-old woman presented 2 weeks after a coronavirus 2019 infection with acute sensory symptoms, distal allodynia, mild weakness, and mild hyporeflexia in her upper limbs. A nerve conduction study (NCS) showed delayed motor distal latencies, and lumbar puncture confirmed cytoalbuminologic dissociation. After excluding other etiologies, she was diagnosed with GBS, treated with an IV immunoglobulin course, and showed remarkable recovery. Results of a repeat NCS were consistent with RCF and confirmed the presence of axonal GBS. Increased awareness of sensory GBS and RCF is expected to improve the diagnosis and management of atypical GBS presentations.
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spelling pubmed-99876312023-03-07 Post COVID-19 Guillain–Barre syndrome presents as sensory dominant neuropathy with reversible conduction failure AlTahan, Abdulrahman M. AlAnazi, Mohammed H. AlTahan, Faisal A. AlAbandi, Fatima A. Neurosciences (Riyadh) Case Report Guillain–Barré syndrome (GBS) has several clinical variants. The sensory presentations of GBS are atypical but well-recognized. We report a patient who presented with predominantly sensory symptoms associated with reversible conduction failure (RCF). RCF is a well-defined neurophysiological abnormality noted mainly in axonal GBS and may be misinterpreted as evidence of demyelination. A 25-year-old woman presented 2 weeks after a coronavirus 2019 infection with acute sensory symptoms, distal allodynia, mild weakness, and mild hyporeflexia in her upper limbs. A nerve conduction study (NCS) showed delayed motor distal latencies, and lumbar puncture confirmed cytoalbuminologic dissociation. After excluding other etiologies, she was diagnosed with GBS, treated with an IV immunoglobulin course, and showed remarkable recovery. Results of a repeat NCS were consistent with RCF and confirmed the presence of axonal GBS. Increased awareness of sensory GBS and RCF is expected to improve the diagnosis and management of atypical GBS presentations. Riyadh : Armed Forces Hospital 2023-01 /pmc/articles/PMC9987631/ /pubmed/36617454 http://dx.doi.org/10.17712/nsj.2023.1.20220057 Text en Copyright: © Neurosciences https://creativecommons.org/licenses/by-nc/3.0/Neurosciences is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work.
spellingShingle Case Report
AlTahan, Abdulrahman M.
AlAnazi, Mohammed H.
AlTahan, Faisal A.
AlAbandi, Fatima A.
Post COVID-19 Guillain–Barre syndrome presents as sensory dominant neuropathy with reversible conduction failure
title Post COVID-19 Guillain–Barre syndrome presents as sensory dominant neuropathy with reversible conduction failure
title_full Post COVID-19 Guillain–Barre syndrome presents as sensory dominant neuropathy with reversible conduction failure
title_fullStr Post COVID-19 Guillain–Barre syndrome presents as sensory dominant neuropathy with reversible conduction failure
title_full_unstemmed Post COVID-19 Guillain–Barre syndrome presents as sensory dominant neuropathy with reversible conduction failure
title_short Post COVID-19 Guillain–Barre syndrome presents as sensory dominant neuropathy with reversible conduction failure
title_sort post covid-19 guillain–barre syndrome presents as sensory dominant neuropathy with reversible conduction failure
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9987631/
https://www.ncbi.nlm.nih.gov/pubmed/36617454
http://dx.doi.org/10.17712/nsj.2023.1.20220057
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