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Impact of diabetes mellitus and co-morbidities on mortality in patients with COVID-19: A single-center retrospective study

OBJECTIVES: To describe the effect of diabetes mellitus (DM) on clinical outcomes of patients admitted with COVID-19 infection. METHODS: We carried out a single center, observational, retrospective study. We included adult patients with laboratory-confirmed diagnosis of COVID-19 admitted to a tertia...

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Autores principales: Sindi, Anees A., Tashkandi, Wail A., Jastaniah, Mohammed W., Bashanfar, Mohammed A., Fakhri, Ahmed F., Alsallum, Fahad S., Alguydi, Hamdan B., Elhazmi, Alyaa, Al-Khatib, Talal A., Alawi, Maha M., Abushoshah, Ibrahim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Saudi Medical Journal 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9987682/
https://www.ncbi.nlm.nih.gov/pubmed/36634951
http://dx.doi.org/10.15537/smj.2023.44.1.20220462
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author Sindi, Anees A.
Tashkandi, Wail A.
Jastaniah, Mohammed W.
Bashanfar, Mohammed A.
Fakhri, Ahmed F.
Alsallum, Fahad S.
Alguydi, Hamdan B.
Elhazmi, Alyaa
Al-Khatib, Talal A.
Alawi, Maha M.
Abushoshah, Ibrahim
author_facet Sindi, Anees A.
Tashkandi, Wail A.
Jastaniah, Mohammed W.
Bashanfar, Mohammed A.
Fakhri, Ahmed F.
Alsallum, Fahad S.
Alguydi, Hamdan B.
Elhazmi, Alyaa
Al-Khatib, Talal A.
Alawi, Maha M.
Abushoshah, Ibrahim
author_sort Sindi, Anees A.
collection PubMed
description OBJECTIVES: To describe the effect of diabetes mellitus (DM) on clinical outcomes of patients admitted with COVID-19 infection. METHODS: We carried out a single center, observational, retrospective study. We included adult patients with laboratory-confirmed diagnosis of COVID-19 admitted to a tertiary hospital in Jeddah, Saudi Arabia, from April 2020 to December 2020. Electronic medical records were reviewed for demographics, clinical status, hospital course, and outcome; and they were compared between the patients with or without DM. RESULTS: Out of 198 patients included in the study, 86 (43.4%) were diabetic and 112 (56.5%) were non-diabetic. Majority of the patients were males 139 (70.2%) with a mean age of 54.14±14.89 years. In-hospital mortality rate was higher in diabetic patients than in non-diabetic patients (40 vs. 32; p=0.011). The most common comorbidity was hypertension (n=95, 48%) followed by ischemic heart disease (n=35, 17.7%), chronic kidney disease (n=17, 9.6%), and bronchial asthma (n=10, 5.1%). CONCLUSION: The risk of SARS-CoV-2 infection is higher among diabetic patients; particularly, those with preexisting co-morbidities or geriatric patients. Diabetic patients are prone to a severe clinical course of COVID-19 and a significantly higher mortality rate.
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spelling pubmed-99876822023-03-07 Impact of diabetes mellitus and co-morbidities on mortality in patients with COVID-19: A single-center retrospective study Sindi, Anees A. Tashkandi, Wail A. Jastaniah, Mohammed W. Bashanfar, Mohammed A. Fakhri, Ahmed F. Alsallum, Fahad S. Alguydi, Hamdan B. Elhazmi, Alyaa Al-Khatib, Talal A. Alawi, Maha M. Abushoshah, Ibrahim Saudi Med J Original Article OBJECTIVES: To describe the effect of diabetes mellitus (DM) on clinical outcomes of patients admitted with COVID-19 infection. METHODS: We carried out a single center, observational, retrospective study. We included adult patients with laboratory-confirmed diagnosis of COVID-19 admitted to a tertiary hospital in Jeddah, Saudi Arabia, from April 2020 to December 2020. Electronic medical records were reviewed for demographics, clinical status, hospital course, and outcome; and they were compared between the patients with or without DM. RESULTS: Out of 198 patients included in the study, 86 (43.4%) were diabetic and 112 (56.5%) were non-diabetic. Majority of the patients were males 139 (70.2%) with a mean age of 54.14±14.89 years. In-hospital mortality rate was higher in diabetic patients than in non-diabetic patients (40 vs. 32; p=0.011). The most common comorbidity was hypertension (n=95, 48%) followed by ischemic heart disease (n=35, 17.7%), chronic kidney disease (n=17, 9.6%), and bronchial asthma (n=10, 5.1%). CONCLUSION: The risk of SARS-CoV-2 infection is higher among diabetic patients; particularly, those with preexisting co-morbidities or geriatric patients. Diabetic patients are prone to a severe clinical course of COVID-19 and a significantly higher mortality rate. Saudi Medical Journal 2023-01 /pmc/articles/PMC9987682/ /pubmed/36634951 http://dx.doi.org/10.15537/smj.2023.44.1.20220462 Text en Copyright: © Saudi Medical Journal https://creativecommons.org/licenses/by/4.0/This is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work.
spellingShingle Original Article
Sindi, Anees A.
Tashkandi, Wail A.
Jastaniah, Mohammed W.
Bashanfar, Mohammed A.
Fakhri, Ahmed F.
Alsallum, Fahad S.
Alguydi, Hamdan B.
Elhazmi, Alyaa
Al-Khatib, Talal A.
Alawi, Maha M.
Abushoshah, Ibrahim
Impact of diabetes mellitus and co-morbidities on mortality in patients with COVID-19: A single-center retrospective study
title Impact of diabetes mellitus and co-morbidities on mortality in patients with COVID-19: A single-center retrospective study
title_full Impact of diabetes mellitus and co-morbidities on mortality in patients with COVID-19: A single-center retrospective study
title_fullStr Impact of diabetes mellitus and co-morbidities on mortality in patients with COVID-19: A single-center retrospective study
title_full_unstemmed Impact of diabetes mellitus and co-morbidities on mortality in patients with COVID-19: A single-center retrospective study
title_short Impact of diabetes mellitus and co-morbidities on mortality in patients with COVID-19: A single-center retrospective study
title_sort impact of diabetes mellitus and co-morbidities on mortality in patients with covid-19: a single-center retrospective study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9987682/
https://www.ncbi.nlm.nih.gov/pubmed/36634951
http://dx.doi.org/10.15537/smj.2023.44.1.20220462
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