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Reproductive outcomes in couples with sporadic miscarriage after embryonic chromosomal microarray analysis

OBJECTIVES: Chromosomal microarray analysis (CMA) has been widely applied to genetic diagnosis in miscarriages in clinical practice. However, the prognostic value of CMA testing of products of conception (POCs) after the first clinical miscarriage remains unknown. The aim of this study was to evalua...

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Autores principales: Xia, Zhengyi, Zhou, Ran, Li, Yiming, Meng, Lulu, Huang, Mingtao, Tan, Jianxin, Qiao, Fengchang, Zhu, Hui, Hu, Ping, Zhu, Qiaoying, Xu, Zhengfeng, Wang, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9987763/
https://www.ncbi.nlm.nih.gov/pubmed/36869707
http://dx.doi.org/10.1080/07853890.2023.2183986
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author Xia, Zhengyi
Zhou, Ran
Li, Yiming
Meng, Lulu
Huang, Mingtao
Tan, Jianxin
Qiao, Fengchang
Zhu, Hui
Hu, Ping
Zhu, Qiaoying
Xu, Zhengfeng
Wang, Yan
author_facet Xia, Zhengyi
Zhou, Ran
Li, Yiming
Meng, Lulu
Huang, Mingtao
Tan, Jianxin
Qiao, Fengchang
Zhu, Hui
Hu, Ping
Zhu, Qiaoying
Xu, Zhengfeng
Wang, Yan
author_sort Xia, Zhengyi
collection PubMed
description OBJECTIVES: Chromosomal microarray analysis (CMA) has been widely applied to genetic diagnosis in miscarriages in clinical practice. However, the prognostic value of CMA testing of products of conception (POCs) after the first clinical miscarriage remains unknown. The aim of this study was to evaluate the reproductive outcomes after embryonic genetic testing by CMA in SM couples. METHODS: In this retrospective study, a total of 1142 SM couples referred for embryonic genetic testing by CMA, and 1022 couples were successfully followed up after CMA. RESULTS: Among 1130 cases without significant maternal cell contamination, pathogenic chromosomal abnormalities were detected in 680 cases (60.2%). The subsequent live birth rate did not differ significantly between couples with chromosomally abnormal and normal miscarriage (88.6% vs. 91.1%, p = .240), as well as the cumulative live birth rate (94.5% vs. 96.7%, p = .131). Couples with partial aneuploid miscarriage had a higher likelihood of spontaneous abortion both in the subsequent pregnancy (19.0% vs. 6.5%, p = .037) and cumulative pregnancies (19.0% vs. 6.8%, p = .044) when compared with couples with chromosomally normal miscarriage. CONCLUSIONS: KEY MESSAGES: CMA testing of POCs could provide an accurate genetic diagnosis for couples with SM. The live birth rate of couples with partial aneuploid miscarriage was as high as couples with chromosomally normal miscarriage, despite a higher risk of adverse pregnancy event. Among couples with the most common single aneuploid miscarriage, the cumulative live birth rates of couples with trisomy 16, sex chromosomal abnormalities and trisomy 22 were 94.1%, 95.8% and 84.0%, respectively.
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spelling pubmed-99877632023-03-07 Reproductive outcomes in couples with sporadic miscarriage after embryonic chromosomal microarray analysis Xia, Zhengyi Zhou, Ran Li, Yiming Meng, Lulu Huang, Mingtao Tan, Jianxin Qiao, Fengchang Zhu, Hui Hu, Ping Zhu, Qiaoying Xu, Zhengfeng Wang, Yan Ann Med Medical Genetics & Genomics OBJECTIVES: Chromosomal microarray analysis (CMA) has been widely applied to genetic diagnosis in miscarriages in clinical practice. However, the prognostic value of CMA testing of products of conception (POCs) after the first clinical miscarriage remains unknown. The aim of this study was to evaluate the reproductive outcomes after embryonic genetic testing by CMA in SM couples. METHODS: In this retrospective study, a total of 1142 SM couples referred for embryonic genetic testing by CMA, and 1022 couples were successfully followed up after CMA. RESULTS: Among 1130 cases without significant maternal cell contamination, pathogenic chromosomal abnormalities were detected in 680 cases (60.2%). The subsequent live birth rate did not differ significantly between couples with chromosomally abnormal and normal miscarriage (88.6% vs. 91.1%, p = .240), as well as the cumulative live birth rate (94.5% vs. 96.7%, p = .131). Couples with partial aneuploid miscarriage had a higher likelihood of spontaneous abortion both in the subsequent pregnancy (19.0% vs. 6.5%, p = .037) and cumulative pregnancies (19.0% vs. 6.8%, p = .044) when compared with couples with chromosomally normal miscarriage. CONCLUSIONS: KEY MESSAGES: CMA testing of POCs could provide an accurate genetic diagnosis for couples with SM. The live birth rate of couples with partial aneuploid miscarriage was as high as couples with chromosomally normal miscarriage, despite a higher risk of adverse pregnancy event. Among couples with the most common single aneuploid miscarriage, the cumulative live birth rates of couples with trisomy 16, sex chromosomal abnormalities and trisomy 22 were 94.1%, 95.8% and 84.0%, respectively. Taylor & Francis 2023-03-04 /pmc/articles/PMC9987763/ /pubmed/36869707 http://dx.doi.org/10.1080/07853890.2023.2183986 Text en © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Medical Genetics & Genomics
Xia, Zhengyi
Zhou, Ran
Li, Yiming
Meng, Lulu
Huang, Mingtao
Tan, Jianxin
Qiao, Fengchang
Zhu, Hui
Hu, Ping
Zhu, Qiaoying
Xu, Zhengfeng
Wang, Yan
Reproductive outcomes in couples with sporadic miscarriage after embryonic chromosomal microarray analysis
title Reproductive outcomes in couples with sporadic miscarriage after embryonic chromosomal microarray analysis
title_full Reproductive outcomes in couples with sporadic miscarriage after embryonic chromosomal microarray analysis
title_fullStr Reproductive outcomes in couples with sporadic miscarriage after embryonic chromosomal microarray analysis
title_full_unstemmed Reproductive outcomes in couples with sporadic miscarriage after embryonic chromosomal microarray analysis
title_short Reproductive outcomes in couples with sporadic miscarriage after embryonic chromosomal microarray analysis
title_sort reproductive outcomes in couples with sporadic miscarriage after embryonic chromosomal microarray analysis
topic Medical Genetics & Genomics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9987763/
https://www.ncbi.nlm.nih.gov/pubmed/36869707
http://dx.doi.org/10.1080/07853890.2023.2183986
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