Human ACE2 expression, a major tropism determinant for SARS-CoV-2, is regulated by upstream and intragenic elements

Angiotensin-converting enzyme 2 (ACE2), part of the renin-angiotensin system (RAS), serves as an entry point for SARS-CoV-2, leading to viral proliferation in permissive cell types. Using mouse lines in which the Ace2 locus has been humanized by syntenic replacement, we show that regulation of basal...

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Detalles Bibliográficos
Autores principales: Snouwaert, John N., Jania, Leigh A., Nguyen, Trang, Martinez, David R., Schäfer, Alexandra, Catanzaro, Nicholas J., Gully, Kendra L., Baric, Ralph S., Heise, Mark, Ferris, Martin T., Anderson, Elizabeth, Pressey, Katia, Dillard, Jacob A., Taft-Benz, Sharon, Baxter, Victoria K., Ting, Jenny P-Y, Koller, Beverly H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9987828/
https://www.ncbi.nlm.nih.gov/pubmed/36812267
http://dx.doi.org/10.1371/journal.ppat.1011168

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