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Viral subversion of the cell polarity regulator Scribble

Scribble is a scaffolding protein that regulates key events such as cell polarity, tumorigenesis and neuronal signalling. Scribble belongs to the LAP family which comprise of 16 Leucine Rich Repeats (LRR) at the N-terminus, two LAP Specific Domains (LAPSD) and four PSD-95/Discs-large/ZO-1 (PDZ) doma...

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Autores principales: Javorsky, Airah, Humbert, Patrick O., Kvansakul, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9987997/
https://www.ncbi.nlm.nih.gov/pubmed/36606695
http://dx.doi.org/10.1042/BST20221067
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author Javorsky, Airah
Humbert, Patrick O.
Kvansakul, Marc
author_facet Javorsky, Airah
Humbert, Patrick O.
Kvansakul, Marc
author_sort Javorsky, Airah
collection PubMed
description Scribble is a scaffolding protein that regulates key events such as cell polarity, tumorigenesis and neuronal signalling. Scribble belongs to the LAP family which comprise of 16 Leucine Rich Repeats (LRR) at the N-terminus, two LAP Specific Domains (LAPSD) and four PSD-95/Discs-large/ZO-1 (PDZ) domains at the C-terminus. The four PDZ domains have been shown to be key for a range of protein–protein interactions and have been identified to be crucial mediators for the vast majority of Scribble interactions, particularly via PDZ Binding Motifs (PBMs) often found at the C-terminus of interacting proteins. Dysregulation of Scribble is associated with poor prognosis in viral infections due to subversion of multiple cell signalling pathways by viral effector proteins. Here, we review the molecular details of the interplay between Scribble and viral effector proteins that provide insight into the potential modes of regulation of Scribble mediated polarity signalling.
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spelling pubmed-99879972023-03-07 Viral subversion of the cell polarity regulator Scribble Javorsky, Airah Humbert, Patrick O. Kvansakul, Marc Biochem Soc Trans Review Articles Scribble is a scaffolding protein that regulates key events such as cell polarity, tumorigenesis and neuronal signalling. Scribble belongs to the LAP family which comprise of 16 Leucine Rich Repeats (LRR) at the N-terminus, two LAP Specific Domains (LAPSD) and four PSD-95/Discs-large/ZO-1 (PDZ) domains at the C-terminus. The four PDZ domains have been shown to be key for a range of protein–protein interactions and have been identified to be crucial mediators for the vast majority of Scribble interactions, particularly via PDZ Binding Motifs (PBMs) often found at the C-terminus of interacting proteins. Dysregulation of Scribble is associated with poor prognosis in viral infections due to subversion of multiple cell signalling pathways by viral effector proteins. Here, we review the molecular details of the interplay between Scribble and viral effector proteins that provide insight into the potential modes of regulation of Scribble mediated polarity signalling. Portland Press Ltd. 2023-02-27 2023-01-06 /pmc/articles/PMC9987997/ /pubmed/36606695 http://dx.doi.org/10.1042/BST20221067 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (https://creativecommons.org/licenses/by/4.0/) . Open access for this article was enabled by the participation of La Trobe University in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with CAUL.
spellingShingle Review Articles
Javorsky, Airah
Humbert, Patrick O.
Kvansakul, Marc
Viral subversion of the cell polarity regulator Scribble
title Viral subversion of the cell polarity regulator Scribble
title_full Viral subversion of the cell polarity regulator Scribble
title_fullStr Viral subversion of the cell polarity regulator Scribble
title_full_unstemmed Viral subversion of the cell polarity regulator Scribble
title_short Viral subversion of the cell polarity regulator Scribble
title_sort viral subversion of the cell polarity regulator scribble
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9987997/
https://www.ncbi.nlm.nih.gov/pubmed/36606695
http://dx.doi.org/10.1042/BST20221067
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