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The dynamic balance of the skin microbiome across the lifespan

For decades research has centered on identifying the ideal balanced skin microbiome that prevents disease and on developing therapeutics to foster this balance. However, this single idealized balance may not exist. The skin microbiome changes across the lifespan. This is reflected in the dynamic shi...

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Detalles Bibliográficos
Autores principales: Townsend, Elizabeth C., Kalan, Lindsay R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9988004/
https://www.ncbi.nlm.nih.gov/pubmed/36606709
http://dx.doi.org/10.1042/BST20220216
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Kalan, Lindsay R.
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Kalan, Lindsay R.
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description For decades research has centered on identifying the ideal balanced skin microbiome that prevents disease and on developing therapeutics to foster this balance. However, this single idealized balance may not exist. The skin microbiome changes across the lifespan. This is reflected in the dynamic shifts of the skin microbiome's diverse, inter-connected community of microorganisms with age. While there are core skin microbial taxa, the precise community composition for any individual person is determined by local skin physiology, genetics, microbe–host interactions, and microbe–microbe interactions. As a key interface with the environment, the skin surface and its appendages are also constantly exchanging microbes with close personal contacts and the environment. Hormone fluctuations and immune system maturation also drive age-dependent changes in skin physiology that support different microbial community structures over time. Here, we review recent insights into the factors that shape the skin microbiome throughout life. Collectively, the works summarized within this review highlight how, depending on where we are in lifespan, our skin supports robust microbial communities, while still maintaining microbial features unique to us. This review will also highlight how disruptions to this dynamic microbial balance can influence risk for dermatological diseases as well as impact lifelong health.
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spelling pubmed-99880042023-03-07 The dynamic balance of the skin microbiome across the lifespan Townsend, Elizabeth C. Kalan, Lindsay R. Biochem Soc Trans Review Articles For decades research has centered on identifying the ideal balanced skin microbiome that prevents disease and on developing therapeutics to foster this balance. However, this single idealized balance may not exist. The skin microbiome changes across the lifespan. This is reflected in the dynamic shifts of the skin microbiome's diverse, inter-connected community of microorganisms with age. While there are core skin microbial taxa, the precise community composition for any individual person is determined by local skin physiology, genetics, microbe–host interactions, and microbe–microbe interactions. As a key interface with the environment, the skin surface and its appendages are also constantly exchanging microbes with close personal contacts and the environment. Hormone fluctuations and immune system maturation also drive age-dependent changes in skin physiology that support different microbial community structures over time. Here, we review recent insights into the factors that shape the skin microbiome throughout life. Collectively, the works summarized within this review highlight how, depending on where we are in lifespan, our skin supports robust microbial communities, while still maintaining microbial features unique to us. This review will also highlight how disruptions to this dynamic microbial balance can influence risk for dermatological diseases as well as impact lifelong health. Portland Press Ltd. 2023-02-27 2023-01-06 /pmc/articles/PMC9988004/ /pubmed/36606709 http://dx.doi.org/10.1042/BST20220216 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Articles
Townsend, Elizabeth C.
Kalan, Lindsay R.
The dynamic balance of the skin microbiome across the lifespan
title The dynamic balance of the skin microbiome across the lifespan
title_full The dynamic balance of the skin microbiome across the lifespan
title_fullStr The dynamic balance of the skin microbiome across the lifespan
title_full_unstemmed The dynamic balance of the skin microbiome across the lifespan
title_short The dynamic balance of the skin microbiome across the lifespan
title_sort dynamic balance of the skin microbiome across the lifespan
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9988004/
https://www.ncbi.nlm.nih.gov/pubmed/36606709
http://dx.doi.org/10.1042/BST20220216
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