Pharmacokinetic-Interactions of BI 425809, a Novel Glycine Transporter 1 Inhibitor, With Cytochrome P450 and P-Glycoprotein Substrates: Findings From In Vitro Analyses and an Open-Label, Single-Sequence Phase I Study

PURPOSE/BACKGROUND: Glycine transporter-1 inhibitors may ameliorate cognitive deficits in schizophrenia. This study evaluated potential drug-drug interactions with the glycine transporter-1 inhibitor BI 425809. METHODS/PROCEDURES: Interactions with cytochromes P450 (CYP) and P-glycoprotein (P-gp) we...

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Detalles Bibliográficos
Autores principales: Desch, Michael, Schlecker, Christina, Hohl, Kathrin, Liesenfeld, Karl-Heinz, Chan, Tom, Müller, Fabian, Wunderlich, Glen, Keller, Sascha, Ishiguro, Naoki, Wind, Sven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Original Contributions
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9988221/
https://www.ncbi.nlm.nih.gov/pubmed/36700734
http://dx.doi.org/10.1097/JCP.0000000000001656

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