Sildenafil Improves Pulmonary Vascular Remodeling in a Rat Model of Persistent Pulmonary Hypertension of the Newborn

Persistent pulmonary hypertension of the newborn (PPHN) is characterized by pulmonary arterial remodeling mainly because of apoptosis resistance and excessive proliferation of pulmonary artery smooth muscle cells (PASMCs). Sildenafil is a phosphodiesterase-5 inhibitor. Some reports have shown that s...

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Detalles Bibliográficos
Autores principales: Kang, Lili, Liu, Xianghong, Li, Zilong, Li, XiaoMei, Han, Yujie, Liu, Chen, Zhao, Cuifen, Li, Xiaoying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Journal of Cardiovascular Pharmacology 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9988230/
https://www.ncbi.nlm.nih.gov/pubmed/36198097
http://dx.doi.org/10.1097/FJC.0000000000001373

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