Pharmacometrics of high-dose ivermectin in early COVID-19 from an open label, randomized, controlled adaptive platform trial (PLATCOV)

BACKGROUND: There is no generally accepted methodology for in vivo assessment of antiviral activity in SARS-CoV-2 infections. Ivermectin has been recommended widely as a treatment of COVID-19, but whether it has clinically significant antiviral activity in vivo is uncertain. METHODS: In a multicentr...

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Detalles Bibliográficos
Autores principales: Schilling, William HK, Jittamala, Podjanee, Watson, James A, Ekkapongpisit, Maneerat, Siripoon, Tanaya, Ngamprasertchai, Thundon, Luvira, Viravarn, Pongwilai, Sasithorn, Cruz, Cintia, Callery, James J, Boyd, Simon, Kruabkontho, Varaporn, Ngernseng, Thatsanun, Tubprasert, Jaruwan, Abdad, Mohammad Yazid, Piaraksa, Nattaporn, Suwannasin, Kanokon, Hanboonkunupakarn, Pongtorn, Hanboonkunupakarn, Borimas, Sookprome, Sakol, Poovorawan, Kittiyod, Thaipadungpanit, Janjira, Blacksell, Stuart, Imwong, Mallika, Tarning, Joel, Taylor, Walter RJ, Chotivanich, Vasin, Sangketchon, Chunlanee, Ruksakul, Wiroj, Chotivanich, Kesinee, Teixeira, Mauro Martins, Pukrittayakamee, Sasithon, Dondorp, Arjen M, Day, Nicholas PJ, Piyaphanee, Watcharapong, Phumratanaprapin, Weerapong, White, Nicholas J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9988254/
https://www.ncbi.nlm.nih.gov/pubmed/36803992
http://dx.doi.org/10.7554/eLife.83201

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