Palmitoylation and PDE6δ regulate membrane-compartment-specific substrate ubiquitylation and degradation

Substrate degradation by the ubiquitin proteasome system (UPS) in specific membrane compartments remains elusive. Here, we show that the interplay of two lipid modifications and PDE6δ regulates compartmental substrate targeting via the SCF(FBXL2). FBXL2 is palmitoylated in a prenylation-dependent ma...

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Detalles Bibliográficos
Autores principales: Liang, David, Jiang, Liping, Bhat, Sameer Ahmed, Missiroli, Sonia, Perrone, Mariasole, Lauriola, Angela, Adhikari, Ritika, Gudur, Anish, Vasi, Zahra, Ahearn, Ian, Guardavaccaro, Daniele, Giorgi, Carlotta, Philips, Mark, Kuchay, Shafi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9988375/
https://www.ncbi.nlm.nih.gov/pubmed/36662618
http://dx.doi.org/10.1016/j.celrep.2023.111999

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