Sustainable extraction of ligustilide and ferulic acid from Angelicae Sinensis Radix, for antioxidant and anti-inflammatory activities

The 2030 Agenda for Sustainable Development envisions a rational use of energy and resources in all technological processes. However, in the extraction methods of compounds from medicinal plants and herbs, there is an urgent to reduce the use of organic solvents and increase the energy efficiency of...

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Autores principales: Song, Xuejiao, Liu, Chang, Zhang, Yang, Xiao, Xiaoyue, Han, Guorui, Sun, Kedi, Liu, Shuoqi, Zhang, Zhiyun, Dong, Chunliu, Zheng, Yadan, Chen, Xueying, Xu, Tong, Liu, Yanyan, Li, Yanhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9988401/
https://www.ncbi.nlm.nih.gov/pubmed/36871526
http://dx.doi.org/10.1016/j.ultsonch.2023.106344
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author Song, Xuejiao
Liu, Chang
Zhang, Yang
Xiao, Xiaoyue
Han, Guorui
Sun, Kedi
Liu, Shuoqi
Zhang, Zhiyun
Dong, Chunliu
Zheng, Yadan
Chen, Xueying
Xu, Tong
Liu, Yanyan
Li, Yanhua
author_facet Song, Xuejiao
Liu, Chang
Zhang, Yang
Xiao, Xiaoyue
Han, Guorui
Sun, Kedi
Liu, Shuoqi
Zhang, Zhiyun
Dong, Chunliu
Zheng, Yadan
Chen, Xueying
Xu, Tong
Liu, Yanyan
Li, Yanhua
author_sort Song, Xuejiao
collection PubMed
description The 2030 Agenda for Sustainable Development envisions a rational use of energy and resources in all technological processes. However, in the extraction methods of compounds from medicinal plants and herbs, there is an urgent to reduce the use of organic solvents and increase the energy efficiency of these methods. Therefore, a sustainable extraction method (enzyme and ultrasonic co-assisted aqueous two-phase extraction, EUA-ATPE) of simultaneous extraction and separation of ferulic acid and ligustilide from Angelicae Sinensis Radix (ASR) was developed by integrating enzyme-assisted extraction (EAE) with ultrasonic-assisted aqueous two-phase extraction (UAE- ATPE). The effects of different enzymes, extraction temperature, pH, ultrasonic time, liquid-to-materials ratio, etc., were optimized by single-factor experiments and central composite design (CCD). Under the optimum conditions, the highest comprehensive evaluation value (CEV) and extraction yield were obtained by EUA-ATPE. Furthermore, recovery (R), partition coefficient (K), and scanning electron microscopy (SEM) analysis revealed that enzyme and ultrasonic treatment improved mass transfer diffusion and increased the degree of cell disruption. Besides, the EUA-ATPE extracts have shown great antioxidant and anti-inflammatory activity in vitro. Finally, compared to different extraction methods, EUA-ATPE achieved higher extraction efficiency and higher energy efficiency due to the synergistic effect between EAE and UAE-ATPE. Therefore, the EUA-ATPE provides a sustainable method for extracting bioactive compounds from medicinal plants and herbs, contributing to Sustainable Development Goals (SDG), including SDG-6, SDG-7, SDG-9, SDG-12, and SDG-15.
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spelling pubmed-99884012023-03-07 Sustainable extraction of ligustilide and ferulic acid from Angelicae Sinensis Radix, for antioxidant and anti-inflammatory activities Song, Xuejiao Liu, Chang Zhang, Yang Xiao, Xiaoyue Han, Guorui Sun, Kedi Liu, Shuoqi Zhang, Zhiyun Dong, Chunliu Zheng, Yadan Chen, Xueying Xu, Tong Liu, Yanyan Li, Yanhua Ultrason Sonochem Original Research Article The 2030 Agenda for Sustainable Development envisions a rational use of energy and resources in all technological processes. However, in the extraction methods of compounds from medicinal plants and herbs, there is an urgent to reduce the use of organic solvents and increase the energy efficiency of these methods. Therefore, a sustainable extraction method (enzyme and ultrasonic co-assisted aqueous two-phase extraction, EUA-ATPE) of simultaneous extraction and separation of ferulic acid and ligustilide from Angelicae Sinensis Radix (ASR) was developed by integrating enzyme-assisted extraction (EAE) with ultrasonic-assisted aqueous two-phase extraction (UAE- ATPE). The effects of different enzymes, extraction temperature, pH, ultrasonic time, liquid-to-materials ratio, etc., were optimized by single-factor experiments and central composite design (CCD). Under the optimum conditions, the highest comprehensive evaluation value (CEV) and extraction yield were obtained by EUA-ATPE. Furthermore, recovery (R), partition coefficient (K), and scanning electron microscopy (SEM) analysis revealed that enzyme and ultrasonic treatment improved mass transfer diffusion and increased the degree of cell disruption. Besides, the EUA-ATPE extracts have shown great antioxidant and anti-inflammatory activity in vitro. Finally, compared to different extraction methods, EUA-ATPE achieved higher extraction efficiency and higher energy efficiency due to the synergistic effect between EAE and UAE-ATPE. Therefore, the EUA-ATPE provides a sustainable method for extracting bioactive compounds from medicinal plants and herbs, contributing to Sustainable Development Goals (SDG), including SDG-6, SDG-7, SDG-9, SDG-12, and SDG-15. Elsevier 2023-02-24 /pmc/articles/PMC9988401/ /pubmed/36871526 http://dx.doi.org/10.1016/j.ultsonch.2023.106344 Text en © 2023 Published by Elsevier B.V. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Research Article
Song, Xuejiao
Liu, Chang
Zhang, Yang
Xiao, Xiaoyue
Han, Guorui
Sun, Kedi
Liu, Shuoqi
Zhang, Zhiyun
Dong, Chunliu
Zheng, Yadan
Chen, Xueying
Xu, Tong
Liu, Yanyan
Li, Yanhua
Sustainable extraction of ligustilide and ferulic acid from Angelicae Sinensis Radix, for antioxidant and anti-inflammatory activities
title Sustainable extraction of ligustilide and ferulic acid from Angelicae Sinensis Radix, for antioxidant and anti-inflammatory activities
title_full Sustainable extraction of ligustilide and ferulic acid from Angelicae Sinensis Radix, for antioxidant and anti-inflammatory activities
title_fullStr Sustainable extraction of ligustilide and ferulic acid from Angelicae Sinensis Radix, for antioxidant and anti-inflammatory activities
title_full_unstemmed Sustainable extraction of ligustilide and ferulic acid from Angelicae Sinensis Radix, for antioxidant and anti-inflammatory activities
title_short Sustainable extraction of ligustilide and ferulic acid from Angelicae Sinensis Radix, for antioxidant and anti-inflammatory activities
title_sort sustainable extraction of ligustilide and ferulic acid from angelicae sinensis radix, for antioxidant and anti-inflammatory activities
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9988401/
https://www.ncbi.nlm.nih.gov/pubmed/36871526
http://dx.doi.org/10.1016/j.ultsonch.2023.106344
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