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Mendelian randomization and clinical trial evidence supports TYK2 inhibition as a therapeutic target for autoimmune diseases

BACKGROUND: To explore the associations of genetically proxied TYK2 inhibition with a wide range of disease outcomes and biomarkers to identify therapeutic repurposing opportunities, adverse effects, and biomarkers of efficacy. METHODS: The loss-of-function missense variant rs34536443 in TYK2 gene w...

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Detalles Bibliográficos
Autores principales:	Yuan, Shuai, Wang, Lijuan, Zhang, Han, Xu, Fengzhe, Zhou, Xuan, Yu, Lili, Sun, Jing, Chen, Jie, Ying, Haochao, Xu, Xiaolin, Yu, Yongfu, Spiliopoulou, Athina, Shen, Xia, Wilson, Jim, Gill, Dipender, Theodoratou, Evropi, Larsson, Susanna C., Li, Xue
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9988426/ https://www.ncbi.nlm.nih.gov/pubmed/36842216 http://dx.doi.org/10.1016/j.ebiom.2023.104488

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