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Molecular basis of skin photoaging and therapeutic interventions by plant-derived natural product ingredients: A comprehensive review

Skin areas exposed to ultraviolet radiation (UV) from sunlight are more prone to photoaging than unexposed areas evidenced by several signs which include skin dryness, irregular pigmentation, lentigines, hyperpigmentation, wrinkling, and decreased elasticity. Plant-based natural product ingredients...

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Detalles Bibliográficos
Autores principales: Tanveer, Malik A., Rashid, Haroon, Tasduq, Sheikh A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9988502/
https://www.ncbi.nlm.nih.gov/pubmed/36895391
http://dx.doi.org/10.1016/j.heliyon.2023.e13580
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author Tanveer, Malik A.
Rashid, Haroon
Tasduq, Sheikh A.
author_facet Tanveer, Malik A.
Rashid, Haroon
Tasduq, Sheikh A.
author_sort Tanveer, Malik A.
collection PubMed
description Skin areas exposed to ultraviolet radiation (UV) from sunlight are more prone to photoaging than unexposed areas evidenced by several signs which include skin dryness, irregular pigmentation, lentigines, hyperpigmentation, wrinkling, and decreased elasticity. Plant-based natural product ingredients with therapeutic potential against skin photoaging are gaining more attention. This article aims the reviewing the research work done in exploring the cellular and molecular mechanisms involved in UV-induced skin photoaging, followed by summarizing the mechanistic insights involved in its therapeutics by natural product-based ingredients. In the mechanistic section of the convoluted procedure of photoaging, we described the effect of UV radiation (UVR) on different cellular macromolecules (direct damage) and subsequently, the deleterious consequences of UVR-generated reactive oxygen species (indirect damage) and signaling pathways activated or inhibited by UV induced ROS generation in various cellular pathologies of skin photoaging like inflammation, extracellular matrix degradation, apoptosis, mitochondrial dysfunction, and immune suppression. We also discussed the effect of UV radiation on the adipose tissue, and transient receptor potential cation channel V of photoaging skin. In the past few decades, mechanistic studies performed in this area have deciphered various therapeutic targets, opening avenues for different available therapeutic options against this pathological condition. So the remaining portion of the review deals with various natural product-based therapeutic agents available against skin photodamage.
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spelling pubmed-99885022023-03-08 Molecular basis of skin photoaging and therapeutic interventions by plant-derived natural product ingredients: A comprehensive review Tanveer, Malik A. Rashid, Haroon Tasduq, Sheikh A. Heliyon Review Article Skin areas exposed to ultraviolet radiation (UV) from sunlight are more prone to photoaging than unexposed areas evidenced by several signs which include skin dryness, irregular pigmentation, lentigines, hyperpigmentation, wrinkling, and decreased elasticity. Plant-based natural product ingredients with therapeutic potential against skin photoaging are gaining more attention. This article aims the reviewing the research work done in exploring the cellular and molecular mechanisms involved in UV-induced skin photoaging, followed by summarizing the mechanistic insights involved in its therapeutics by natural product-based ingredients. In the mechanistic section of the convoluted procedure of photoaging, we described the effect of UV radiation (UVR) on different cellular macromolecules (direct damage) and subsequently, the deleterious consequences of UVR-generated reactive oxygen species (indirect damage) and signaling pathways activated or inhibited by UV induced ROS generation in various cellular pathologies of skin photoaging like inflammation, extracellular matrix degradation, apoptosis, mitochondrial dysfunction, and immune suppression. We also discussed the effect of UV radiation on the adipose tissue, and transient receptor potential cation channel V of photoaging skin. In the past few decades, mechanistic studies performed in this area have deciphered various therapeutic targets, opening avenues for different available therapeutic options against this pathological condition. So the remaining portion of the review deals with various natural product-based therapeutic agents available against skin photodamage. Elsevier 2023-02-09 /pmc/articles/PMC9988502/ /pubmed/36895391 http://dx.doi.org/10.1016/j.heliyon.2023.e13580 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Tanveer, Malik A.
Rashid, Haroon
Tasduq, Sheikh A.
Molecular basis of skin photoaging and therapeutic interventions by plant-derived natural product ingredients: A comprehensive review
title Molecular basis of skin photoaging and therapeutic interventions by plant-derived natural product ingredients: A comprehensive review
title_full Molecular basis of skin photoaging and therapeutic interventions by plant-derived natural product ingredients: A comprehensive review
title_fullStr Molecular basis of skin photoaging and therapeutic interventions by plant-derived natural product ingredients: A comprehensive review
title_full_unstemmed Molecular basis of skin photoaging and therapeutic interventions by plant-derived natural product ingredients: A comprehensive review
title_short Molecular basis of skin photoaging and therapeutic interventions by plant-derived natural product ingredients: A comprehensive review
title_sort molecular basis of skin photoaging and therapeutic interventions by plant-derived natural product ingredients: a comprehensive review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9988502/
https://www.ncbi.nlm.nih.gov/pubmed/36895391
http://dx.doi.org/10.1016/j.heliyon.2023.e13580
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