Endothelial cell-specific roles for tetrahydrobiopterin in myocardial function, cardiac hypertrophy, and response to myocardial ischemia-reperfusion injury

The cofactor tetrahydrobiopterin (BH(4)) is a critical regulator of nitric oxide synthase (NOS) function and redox signaling, with reduced BH(4) implicated in multiple cardiovascular disease states. In the myocardium, augmentation of BH(4) levels can impact on cardiomyocyte function, preventing hype...

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Detalles Bibliográficos
Autores principales: Chuaiphichai, Surawee, Chu, Sandy M., Carnicer, Ricardo, Kelly, Matthew, Bendall, Jenifer K., Simon, Jillian N., Douglas, Gillian, Crabtree, Mark J., Casadei, Barbara, Channon, Keith M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Physiological Society 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9988535/
https://www.ncbi.nlm.nih.gov/pubmed/36735402
http://dx.doi.org/10.1152/ajpheart.00562.2022

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