Inhibiting O-GlcNAcylation impacts p38 and Erk1/2 signaling and perturbs cardiomyocyte hypertrophy

The dynamic cycling of O-linked GlcNAc (O-GlcNAc) on and off Ser/Thr residues of intracellular proteins, termed O-GlcNAcylation, is mediated by the conserved enzymes O-GlcNAc transferase (OGT) and O-GlcNAcase. O-GlcNAc cycling is important in homeostatic and stress responses, and its perturbation se...

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Detalles Bibliográficos
Autores principales: Papanicolaou, Kyriakos N., Jung, Jessica, Ashok, Deepthi, Zhang, Wenxi, Modaressanavi, Amir, Avila, Eddie, Foster, D. Brian, Zachara, Natasha E., O'Rourke, Brian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9988579/
https://www.ncbi.nlm.nih.gov/pubmed/36642184
http://dx.doi.org/10.1016/j.jbc.2023.102907

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