Bile salt hydrolase of Lactiplantibacillus plantarum plays important roles in amelioration of DSS-induced colitis

Bile salt hydrolases are thought to be the gatekeepers of bile acid metabolism. To study the role of BSH in colitis, we investigated the ameliorative effects of different BSH-knockout strains of Lactiplantibacillus plantarum AR113. The results showed that L. plantarum Δbsh 1 and Δbsh 3 treatments di...

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Autores principales: Feng, Xin, Bu, Zichen, Tang, Hongyu, Xia, Yongjun, Song, Xin, Ai, Lianzhong, Wang, Guangqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9988676/
https://www.ncbi.nlm.nih.gov/pubmed/36895642
http://dx.doi.org/10.1016/j.isci.2023.106196
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author Feng, Xin
Bu, Zichen
Tang, Hongyu
Xia, Yongjun
Song, Xin
Ai, Lianzhong
Wang, Guangqiang
author_facet Feng, Xin
Bu, Zichen
Tang, Hongyu
Xia, Yongjun
Song, Xin
Ai, Lianzhong
Wang, Guangqiang
author_sort Feng, Xin
collection PubMed
description Bile salt hydrolases are thought to be the gatekeepers of bile acid metabolism. To study the role of BSH in colitis, we investigated the ameliorative effects of different BSH-knockout strains of Lactiplantibacillus plantarum AR113. The results showed that L. plantarum Δbsh 1 and Δbsh 3 treatments did not improve body weight and alleviate the hyperactivated myeloperoxidase activity to the DSS group. However, the findings for L. plantarum AR113, L. plantarum Δbsh 2 and Δbsh 4 treatments were completely opposite. The double and triple bsh knockout strains further confirmed that BSH 1 and BSH 3 are critical for the ameliorative effects of L. plantarum AR113. In addition, L. plantarum Δbsh 1 and Δbsh 3 did not significantly inhibit the increase in pro-inflammatory cytokines or the decrease in an anti-inflammatory cytokine. These results suggest that BSH 1 and BSH 3 in L. plantarum play important roles in alleviating enteritis symptoms.
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spelling pubmed-99886762023-03-08 Bile salt hydrolase of Lactiplantibacillus plantarum plays important roles in amelioration of DSS-induced colitis Feng, Xin Bu, Zichen Tang, Hongyu Xia, Yongjun Song, Xin Ai, Lianzhong Wang, Guangqiang iScience Article Bile salt hydrolases are thought to be the gatekeepers of bile acid metabolism. To study the role of BSH in colitis, we investigated the ameliorative effects of different BSH-knockout strains of Lactiplantibacillus plantarum AR113. The results showed that L. plantarum Δbsh 1 and Δbsh 3 treatments did not improve body weight and alleviate the hyperactivated myeloperoxidase activity to the DSS group. However, the findings for L. plantarum AR113, L. plantarum Δbsh 2 and Δbsh 4 treatments were completely opposite. The double and triple bsh knockout strains further confirmed that BSH 1 and BSH 3 are critical for the ameliorative effects of L. plantarum AR113. In addition, L. plantarum Δbsh 1 and Δbsh 3 did not significantly inhibit the increase in pro-inflammatory cytokines or the decrease in an anti-inflammatory cytokine. These results suggest that BSH 1 and BSH 3 in L. plantarum play important roles in alleviating enteritis symptoms. Elsevier 2023-02-13 /pmc/articles/PMC9988676/ /pubmed/36895642 http://dx.doi.org/10.1016/j.isci.2023.106196 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Feng, Xin
Bu, Zichen
Tang, Hongyu
Xia, Yongjun
Song, Xin
Ai, Lianzhong
Wang, Guangqiang
Bile salt hydrolase of Lactiplantibacillus plantarum plays important roles in amelioration of DSS-induced colitis
title Bile salt hydrolase of Lactiplantibacillus plantarum plays important roles in amelioration of DSS-induced colitis
title_full Bile salt hydrolase of Lactiplantibacillus plantarum plays important roles in amelioration of DSS-induced colitis
title_fullStr Bile salt hydrolase of Lactiplantibacillus plantarum plays important roles in amelioration of DSS-induced colitis
title_full_unstemmed Bile salt hydrolase of Lactiplantibacillus plantarum plays important roles in amelioration of DSS-induced colitis
title_short Bile salt hydrolase of Lactiplantibacillus plantarum plays important roles in amelioration of DSS-induced colitis
title_sort bile salt hydrolase of lactiplantibacillus plantarum plays important roles in amelioration of dss-induced colitis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9988676/
https://www.ncbi.nlm.nih.gov/pubmed/36895642
http://dx.doi.org/10.1016/j.isci.2023.106196
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