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Sleep/wake changes in perturbational complexity in rats and mice
In humans, the level of consciousness is assessed by quantifying the spatiotemporal complexity of cortical responses using Perturbational Complexity Index (PCI) and related PCI(st) (st, state transitions). Here we validate PCI(st) in freely moving rats and mice by showing that it is lower in NREM sl...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9988678/ https://www.ncbi.nlm.nih.gov/pubmed/36895652 http://dx.doi.org/10.1016/j.isci.2023.106186 |
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author | Cavelli, Matias Lorenzo Mao, Rong Findlay, Graham Driessen, Kort Bugnon, Tom Tononi, Giulio Cirelli, Chiara |
author_facet | Cavelli, Matias Lorenzo Mao, Rong Findlay, Graham Driessen, Kort Bugnon, Tom Tononi, Giulio Cirelli, Chiara |
author_sort | Cavelli, Matias Lorenzo |
collection | PubMed |
description | In humans, the level of consciousness is assessed by quantifying the spatiotemporal complexity of cortical responses using Perturbational Complexity Index (PCI) and related PCI(st) (st, state transitions). Here we validate PCI(st) in freely moving rats and mice by showing that it is lower in NREM sleep and slow wave anesthesia than in wake or REM sleep, as in humans. We then show that (1) low PCI(st) is associated with the occurrence of an OFF period of neuronal silence; (2) stimulation of deep, but not superficial, cortical layers leads to reliable PCI(st) changes across sleep/wake and anesthesia; (3) consistent PCI(st) changes are independent of which single area is being stimulated or recorded, except for recordings in mouse prefrontal cortex. These experiments show that PCI(st) can reliably measure vigilance states in unresponsive animals and support the hypothesis that it is low when an OFF period disrupts causal interactions in cortical networks. |
format | Online Article Text |
id | pubmed-9988678 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-99886782023-03-08 Sleep/wake changes in perturbational complexity in rats and mice Cavelli, Matias Lorenzo Mao, Rong Findlay, Graham Driessen, Kort Bugnon, Tom Tononi, Giulio Cirelli, Chiara iScience Article In humans, the level of consciousness is assessed by quantifying the spatiotemporal complexity of cortical responses using Perturbational Complexity Index (PCI) and related PCI(st) (st, state transitions). Here we validate PCI(st) in freely moving rats and mice by showing that it is lower in NREM sleep and slow wave anesthesia than in wake or REM sleep, as in humans. We then show that (1) low PCI(st) is associated with the occurrence of an OFF period of neuronal silence; (2) stimulation of deep, but not superficial, cortical layers leads to reliable PCI(st) changes across sleep/wake and anesthesia; (3) consistent PCI(st) changes are independent of which single area is being stimulated or recorded, except for recordings in mouse prefrontal cortex. These experiments show that PCI(st) can reliably measure vigilance states in unresponsive animals and support the hypothesis that it is low when an OFF period disrupts causal interactions in cortical networks. Elsevier 2023-02-13 /pmc/articles/PMC9988678/ /pubmed/36895652 http://dx.doi.org/10.1016/j.isci.2023.106186 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Cavelli, Matias Lorenzo Mao, Rong Findlay, Graham Driessen, Kort Bugnon, Tom Tononi, Giulio Cirelli, Chiara Sleep/wake changes in perturbational complexity in rats and mice |
title | Sleep/wake changes in perturbational complexity in rats and mice |
title_full | Sleep/wake changes in perturbational complexity in rats and mice |
title_fullStr | Sleep/wake changes in perturbational complexity in rats and mice |
title_full_unstemmed | Sleep/wake changes in perturbational complexity in rats and mice |
title_short | Sleep/wake changes in perturbational complexity in rats and mice |
title_sort | sleep/wake changes in perturbational complexity in rats and mice |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9988678/ https://www.ncbi.nlm.nih.gov/pubmed/36895652 http://dx.doi.org/10.1016/j.isci.2023.106186 |
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