SPHINX-Based Combination Therapy as a Potential Novel Treatment Strategy for Acute Myeloid Leukaemia

Introduction: Dysregulated alternative splicing is a prominent feature of cancer. The inhibition and knockdown of the SR splice factor kinase SRPK1 reduces tumour growth in vivo. As a result several SPRK1 inhibitors are in development including SPHINX, a 3-(trifluoromethyl)anilide scaffold. The obje...

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Detalles Bibliográficos
Autores principales: Wodi, Chigeru, Belali, Tareg, Morse, Ruth, Porazinski, Sean, Ladomery, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Health Archive
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9988938/
https://www.ncbi.nlm.nih.gov/pubmed/36895328
http://dx.doi.org/10.3389/bjbs.2023.11041

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9988938/
https://www.ncbi.nlm.nih.gov/pubmed/36895328
http://dx.doi.org/10.3389/bjbs.2023.11041

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