Cargando…

Type 2 diabetes and glycemic traits are not causal factors of delirium: A two-sample mendelian randomization analysis

This study aims to explore the genetic causal association between type 2 diabetes (T2D) and glycemic traits (fasting glucose [FG], fasting insulin [FI], and glycated hemoglobin [HbA1c]) on delirium using Mendelian randomization (MR). Genome-wide association studies (GWAS) summary data for T2D and gl...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Jing, Yang, Mingyi, Luo, Pan, Wang, Gang, Dong, Buhuai, Xu, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9988945/
https://www.ncbi.nlm.nih.gov/pubmed/36896238
http://dx.doi.org/10.3389/fgene.2023.1087878
_version_ 1784901678070235136
author Li, Jing
Yang, Mingyi
Luo, Pan
Wang, Gang
Dong, Buhuai
Xu, Peng
author_facet Li, Jing
Yang, Mingyi
Luo, Pan
Wang, Gang
Dong, Buhuai
Xu, Peng
author_sort Li, Jing
collection PubMed
description This study aims to explore the genetic causal association between type 2 diabetes (T2D) and glycemic traits (fasting glucose [FG], fasting insulin [FI], and glycated hemoglobin [HbA1c]) on delirium using Mendelian randomization (MR). Genome-wide association studies (GWAS) summary data for T2D and glycemic traits were obtained from the IEU OpenGWAS database. GWAS summary data for delirium were obtained from the FinnGen Consortium. All the participants were of European ancestry. In addition, we used T2D, FG, FI, and HbA1c as exposures and delirium as outcomes. A random-effects variance-weighted model (IVW), MR Egger, weighted median, simple mode, and weighted mode were used to perform MR analysis. In addition, MR-IVW and MR-Egger analyses were used to detect heterogeneity in the MR results. Horizontal pleiotropy was detected using MR-Egger regression and MR pleiotropy residual sum and outliers (MR-PRESSO). MR-PRESSO was also used to assess outlier single nucleotide polymorphisms (SNPs). The “leave one out” analysis was used to investigate whether the MR analysis results were influenced by a single SNP and evaluate the robustness of the results. In this study, we conducted a two-sample MR analysis, and there was no evidence of a genetic causal association between T2D and glycemic traits (T2D, FG, FI, and HbA1c) on delirium (all p > 0.05). The MR-IVW and MR-Egger tests showed no heterogeneity in our MR results (all p values >0.05). In addition, The MR-Egger and MR-PRESSO tests showed no horizontal pleiotropy in our MR results (all p > 0.05). The MR-PRESSO results also showed that there were no outliers during the MR analysis. In addition, the “leave one out” test did not find that the SNPs included in the analysis could affect the stability of the MR results. Therefore, our study did not support the causal effects of T2D and glycemic traits (FG, FI, and HbA1c) on delirium risk.
format Online
Article
Text
id pubmed-9988945
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-99889452023-03-08 Type 2 diabetes and glycemic traits are not causal factors of delirium: A two-sample mendelian randomization analysis Li, Jing Yang, Mingyi Luo, Pan Wang, Gang Dong, Buhuai Xu, Peng Front Genet Genetics This study aims to explore the genetic causal association between type 2 diabetes (T2D) and glycemic traits (fasting glucose [FG], fasting insulin [FI], and glycated hemoglobin [HbA1c]) on delirium using Mendelian randomization (MR). Genome-wide association studies (GWAS) summary data for T2D and glycemic traits were obtained from the IEU OpenGWAS database. GWAS summary data for delirium were obtained from the FinnGen Consortium. All the participants were of European ancestry. In addition, we used T2D, FG, FI, and HbA1c as exposures and delirium as outcomes. A random-effects variance-weighted model (IVW), MR Egger, weighted median, simple mode, and weighted mode were used to perform MR analysis. In addition, MR-IVW and MR-Egger analyses were used to detect heterogeneity in the MR results. Horizontal pleiotropy was detected using MR-Egger regression and MR pleiotropy residual sum and outliers (MR-PRESSO). MR-PRESSO was also used to assess outlier single nucleotide polymorphisms (SNPs). The “leave one out” analysis was used to investigate whether the MR analysis results were influenced by a single SNP and evaluate the robustness of the results. In this study, we conducted a two-sample MR analysis, and there was no evidence of a genetic causal association between T2D and glycemic traits (T2D, FG, FI, and HbA1c) on delirium (all p > 0.05). The MR-IVW and MR-Egger tests showed no heterogeneity in our MR results (all p values >0.05). In addition, The MR-Egger and MR-PRESSO tests showed no horizontal pleiotropy in our MR results (all p > 0.05). The MR-PRESSO results also showed that there were no outliers during the MR analysis. In addition, the “leave one out” test did not find that the SNPs included in the analysis could affect the stability of the MR results. Therefore, our study did not support the causal effects of T2D and glycemic traits (FG, FI, and HbA1c) on delirium risk. Frontiers Media S.A. 2023-02-21 /pmc/articles/PMC9988945/ /pubmed/36896238 http://dx.doi.org/10.3389/fgene.2023.1087878 Text en Copyright © 2023 Li, Yang, Luo, Wang, Dong and Xu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Li, Jing
Yang, Mingyi
Luo, Pan
Wang, Gang
Dong, Buhuai
Xu, Peng
Type 2 diabetes and glycemic traits are not causal factors of delirium: A two-sample mendelian randomization analysis
title Type 2 diabetes and glycemic traits are not causal factors of delirium: A two-sample mendelian randomization analysis
title_full Type 2 diabetes and glycemic traits are not causal factors of delirium: A two-sample mendelian randomization analysis
title_fullStr Type 2 diabetes and glycemic traits are not causal factors of delirium: A two-sample mendelian randomization analysis
title_full_unstemmed Type 2 diabetes and glycemic traits are not causal factors of delirium: A two-sample mendelian randomization analysis
title_short Type 2 diabetes and glycemic traits are not causal factors of delirium: A two-sample mendelian randomization analysis
title_sort type 2 diabetes and glycemic traits are not causal factors of delirium: a two-sample mendelian randomization analysis
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9988945/
https://www.ncbi.nlm.nih.gov/pubmed/36896238
http://dx.doi.org/10.3389/fgene.2023.1087878
work_keys_str_mv AT lijing type2diabetesandglycemictraitsarenotcausalfactorsofdeliriumatwosamplemendelianrandomizationanalysis
AT yangmingyi type2diabetesandglycemictraitsarenotcausalfactorsofdeliriumatwosamplemendelianrandomizationanalysis
AT luopan type2diabetesandglycemictraitsarenotcausalfactorsofdeliriumatwosamplemendelianrandomizationanalysis
AT wanggang type2diabetesandglycemictraitsarenotcausalfactorsofdeliriumatwosamplemendelianrandomizationanalysis
AT dongbuhuai type2diabetesandglycemictraitsarenotcausalfactorsofdeliriumatwosamplemendelianrandomizationanalysis
AT xupeng type2diabetesandglycemictraitsarenotcausalfactorsofdeliriumatwosamplemendelianrandomizationanalysis