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Requirement for ER-mitochondria Ca(2+) transfer, ROS production and mPTP formation in L-asparaginase-induced apoptosis of acute lymphoblastic leukemia cells

Acute lymphoblastic leukemia (aLL) is a malignant cancer in the blood and bone marrow characterized by rapid expansion of lymphoblasts. It is a common pediatric cancer and the principal basis of cancer death in children. Previously, we reported that L-asparaginase, a key component of acute lymphobla...

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Detalles Bibliográficos
Autores principales: Lee, Jung Kwon, Rosales, Jesusa L., Lee, Ki-Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9988955/
https://www.ncbi.nlm.nih.gov/pubmed/36895789
http://dx.doi.org/10.3389/fcell.2023.1124164

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