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The potential regulatory role of the lncRNA-miRNA-mRNA axis in teleost fish

Research over the past two decades has confirmed that noncoding RNAs (ncRNAs), which are abundant in cells from yeast to vertebrates, are no longer “junk” transcripts but functional regulators that can mediate various cellular and physiological processes. The dysregulation of ncRNAs is closely relat...

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Autores principales: Zhou, Zhixia, Leng, Cuibo, Wang, Zhan, Long, Linhai, Lv, Yiju, Gao, Ziru, Wang, Yin, Wang, Shoushi, Li, Peifeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9988957/
https://www.ncbi.nlm.nih.gov/pubmed/36895573
http://dx.doi.org/10.3389/fimmu.2023.1065357
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author Zhou, Zhixia
Leng, Cuibo
Wang, Zhan
Long, Linhai
Lv, Yiju
Gao, Ziru
Wang, Yin
Wang, Shoushi
Li, Peifeng
author_facet Zhou, Zhixia
Leng, Cuibo
Wang, Zhan
Long, Linhai
Lv, Yiju
Gao, Ziru
Wang, Yin
Wang, Shoushi
Li, Peifeng
author_sort Zhou, Zhixia
collection PubMed
description Research over the past two decades has confirmed that noncoding RNAs (ncRNAs), which are abundant in cells from yeast to vertebrates, are no longer “junk” transcripts but functional regulators that can mediate various cellular and physiological processes. The dysregulation of ncRNAs is closely related to the imbalance of cellular homeostasis and the occurrence and development of various diseases. In mammals, ncRNAs, such as long noncoding RNAs (lncRNAs) and microRNAs (miRNAs), have been shown to serve as biomarkers and intervention targets in growth, development, immunity, and disease progression. The regulatory functions of lncRNAs on gene expression are usually mediated by crosstalk with miRNAs. The most predominant mode of lncRNA-miRNA crosstalk is the lncRNA-miRNA-mRNA axis, in which lncRNAs act as competing endogenous RNAs (ceRNAs). Compared to mammals, little attention has been given to the role and mechanism of the lncRNA-miRNA-mRNA axis in teleost species. In this review, we provide current knowledge about the teleost lncRNA-miRNA-mRNA axis, focusing on its physiological and pathological regulation in growth and development, reproduction, skeletal muscle, immunity to bacterial and viral infections, and other stress-related immune responses. Herein, we also explored the potential application of the lncRNA-miRNA-mRNA axis in the aquaculture industry. These findings contribute to an enhanced understanding of ncRNA and ncRNA-ncRNA crosstalk in fish biology to improve aquaculture productivity, fish health and quality.
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spelling pubmed-99889572023-03-08 The potential regulatory role of the lncRNA-miRNA-mRNA axis in teleost fish Zhou, Zhixia Leng, Cuibo Wang, Zhan Long, Linhai Lv, Yiju Gao, Ziru Wang, Yin Wang, Shoushi Li, Peifeng Front Immunol Immunology Research over the past two decades has confirmed that noncoding RNAs (ncRNAs), which are abundant in cells from yeast to vertebrates, are no longer “junk” transcripts but functional regulators that can mediate various cellular and physiological processes. The dysregulation of ncRNAs is closely related to the imbalance of cellular homeostasis and the occurrence and development of various diseases. In mammals, ncRNAs, such as long noncoding RNAs (lncRNAs) and microRNAs (miRNAs), have been shown to serve as biomarkers and intervention targets in growth, development, immunity, and disease progression. The regulatory functions of lncRNAs on gene expression are usually mediated by crosstalk with miRNAs. The most predominant mode of lncRNA-miRNA crosstalk is the lncRNA-miRNA-mRNA axis, in which lncRNAs act as competing endogenous RNAs (ceRNAs). Compared to mammals, little attention has been given to the role and mechanism of the lncRNA-miRNA-mRNA axis in teleost species. In this review, we provide current knowledge about the teleost lncRNA-miRNA-mRNA axis, focusing on its physiological and pathological regulation in growth and development, reproduction, skeletal muscle, immunity to bacterial and viral infections, and other stress-related immune responses. Herein, we also explored the potential application of the lncRNA-miRNA-mRNA axis in the aquaculture industry. These findings contribute to an enhanced understanding of ncRNA and ncRNA-ncRNA crosstalk in fish biology to improve aquaculture productivity, fish health and quality. Frontiers Media S.A. 2023-02-21 /pmc/articles/PMC9988957/ /pubmed/36895573 http://dx.doi.org/10.3389/fimmu.2023.1065357 Text en Copyright © 2023 Zhou, Leng, Wang, Long, Lv, Gao, Wang, Wang and Li https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Zhou, Zhixia
Leng, Cuibo
Wang, Zhan
Long, Linhai
Lv, Yiju
Gao, Ziru
Wang, Yin
Wang, Shoushi
Li, Peifeng
The potential regulatory role of the lncRNA-miRNA-mRNA axis in teleost fish
title The potential regulatory role of the lncRNA-miRNA-mRNA axis in teleost fish
title_full The potential regulatory role of the lncRNA-miRNA-mRNA axis in teleost fish
title_fullStr The potential regulatory role of the lncRNA-miRNA-mRNA axis in teleost fish
title_full_unstemmed The potential regulatory role of the lncRNA-miRNA-mRNA axis in teleost fish
title_short The potential regulatory role of the lncRNA-miRNA-mRNA axis in teleost fish
title_sort potential regulatory role of the lncrna-mirna-mrna axis in teleost fish
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9988957/
https://www.ncbi.nlm.nih.gov/pubmed/36895573
http://dx.doi.org/10.3389/fimmu.2023.1065357
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