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Regulatory mechanisms of microRNAs in endocrine disorders and their therapeutic potential

MicroRNAs (miRNAs) are small endogenous non-coding RNA molecules capable of regulating gene expression at the post-transcriptional level either by translational inhibition or mRNA degradation and have recently been importantly related to the diagnosis and prognosis of the most relevant endocrine dis...

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Autores principales: Ledesma-Pacheco, S. Janin, Uriostegui-Pena, Andrea G., Rodriguez-Jacinto, Estefania, Gomez-Hernandez, Elizabeth, Estrada-Meza, Carolina, Banerjee, Antara, Pathak, Surajit, Ruiz-Manriquez, Luis M., Duttaroy, Asim K., Paul, Sujay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9989203/
https://www.ncbi.nlm.nih.gov/pubmed/36896239
http://dx.doi.org/10.3389/fgene.2023.1137017
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author Ledesma-Pacheco, S. Janin
Uriostegui-Pena, Andrea G.
Rodriguez-Jacinto, Estefania
Gomez-Hernandez, Elizabeth
Estrada-Meza, Carolina
Banerjee, Antara
Pathak, Surajit
Ruiz-Manriquez, Luis M.
Duttaroy, Asim K.
Paul, Sujay
author_facet Ledesma-Pacheco, S. Janin
Uriostegui-Pena, Andrea G.
Rodriguez-Jacinto, Estefania
Gomez-Hernandez, Elizabeth
Estrada-Meza, Carolina
Banerjee, Antara
Pathak, Surajit
Ruiz-Manriquez, Luis M.
Duttaroy, Asim K.
Paul, Sujay
author_sort Ledesma-Pacheco, S. Janin
collection PubMed
description MicroRNAs (miRNAs) are small endogenous non-coding RNA molecules capable of regulating gene expression at the post-transcriptional level either by translational inhibition or mRNA degradation and have recently been importantly related to the diagnosis and prognosis of the most relevant endocrine disorders. The endocrine system comprises various highly vascularized ductless organs regulating metabolism, growth and development, and sexual function. Endocrine disorders constitute the fifth principal cause of death worldwide, and they are considered a significant public health problem due to their long-term effects and negative impact on the patient’s quality of life. Over the last few years, miRNAs have been discovered to regulate various biological processes associated with endocrine disorders, which could be advantageous in developing new diagnostic and therapeutic tools. The present review aims to provide an overview of the most recent and significant information regarding the regulatory mechanism of miRNAs during the development of the most relevant endocrine disorders, including diabetes mellitus, thyroid diseases, osteoporosis, pituitary tumors, Cushing’s syndrome, adrenal insufficiency and multiple endocrine neoplasia, and their potential implications as disease biomarkers.
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spelling pubmed-99892032023-03-08 Regulatory mechanisms of microRNAs in endocrine disorders and their therapeutic potential Ledesma-Pacheco, S. Janin Uriostegui-Pena, Andrea G. Rodriguez-Jacinto, Estefania Gomez-Hernandez, Elizabeth Estrada-Meza, Carolina Banerjee, Antara Pathak, Surajit Ruiz-Manriquez, Luis M. Duttaroy, Asim K. Paul, Sujay Front Genet Genetics MicroRNAs (miRNAs) are small endogenous non-coding RNA molecules capable of regulating gene expression at the post-transcriptional level either by translational inhibition or mRNA degradation and have recently been importantly related to the diagnosis and prognosis of the most relevant endocrine disorders. The endocrine system comprises various highly vascularized ductless organs regulating metabolism, growth and development, and sexual function. Endocrine disorders constitute the fifth principal cause of death worldwide, and they are considered a significant public health problem due to their long-term effects and negative impact on the patient’s quality of life. Over the last few years, miRNAs have been discovered to regulate various biological processes associated with endocrine disorders, which could be advantageous in developing new diagnostic and therapeutic tools. The present review aims to provide an overview of the most recent and significant information regarding the regulatory mechanism of miRNAs during the development of the most relevant endocrine disorders, including diabetes mellitus, thyroid diseases, osteoporosis, pituitary tumors, Cushing’s syndrome, adrenal insufficiency and multiple endocrine neoplasia, and their potential implications as disease biomarkers. Frontiers Media S.A. 2023-02-21 /pmc/articles/PMC9989203/ /pubmed/36896239 http://dx.doi.org/10.3389/fgene.2023.1137017 Text en Copyright © 2023 Ledesma-Pacheco, Uriostegui-Pena, Rodriguez-Jacinto, Gomez-Hernandez, Estrada-Meza, Banerjee, Pathak, Ruiz-Manriquez, Duttaroy and Paul. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Ledesma-Pacheco, S. Janin
Uriostegui-Pena, Andrea G.
Rodriguez-Jacinto, Estefania
Gomez-Hernandez, Elizabeth
Estrada-Meza, Carolina
Banerjee, Antara
Pathak, Surajit
Ruiz-Manriquez, Luis M.
Duttaroy, Asim K.
Paul, Sujay
Regulatory mechanisms of microRNAs in endocrine disorders and their therapeutic potential
title Regulatory mechanisms of microRNAs in endocrine disorders and their therapeutic potential
title_full Regulatory mechanisms of microRNAs in endocrine disorders and their therapeutic potential
title_fullStr Regulatory mechanisms of microRNAs in endocrine disorders and their therapeutic potential
title_full_unstemmed Regulatory mechanisms of microRNAs in endocrine disorders and their therapeutic potential
title_short Regulatory mechanisms of microRNAs in endocrine disorders and their therapeutic potential
title_sort regulatory mechanisms of micrornas in endocrine disorders and their therapeutic potential
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9989203/
https://www.ncbi.nlm.nih.gov/pubmed/36896239
http://dx.doi.org/10.3389/fgene.2023.1137017
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