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Heterogeneity of antibody-secreting cells infiltrating autoimmune tissues
The humoral response is frequently dysfunctioning in autoimmunity with a frequent rise in total serum immunoglobulins, among which are found autoantibodies that may be pathogenic by themselves and/or propagate the inflammatory reaction. The infiltration of autoimmune tissues by antibody-secreting ce...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9989216/ https://www.ncbi.nlm.nih.gov/pubmed/36895558 http://dx.doi.org/10.3389/fimmu.2023.1111366 |
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author | Giovannini, Diane Belbezier, Aude Baillet, Athan Bouillet, Laurence Kawano, Mitsuhiro Dumestre-Perard, Chantal Clavarino, Giovanna Noble, Johan Pers, Jacques-Olivier Sturm, Nathalie Huard, Bertrand |
author_facet | Giovannini, Diane Belbezier, Aude Baillet, Athan Bouillet, Laurence Kawano, Mitsuhiro Dumestre-Perard, Chantal Clavarino, Giovanna Noble, Johan Pers, Jacques-Olivier Sturm, Nathalie Huard, Bertrand |
author_sort | Giovannini, Diane |
collection | PubMed |
description | The humoral response is frequently dysfunctioning in autoimmunity with a frequent rise in total serum immunoglobulins, among which are found autoantibodies that may be pathogenic by themselves and/or propagate the inflammatory reaction. The infiltration of autoimmune tissues by antibody-secreting cells (ASCs) constitutes another dysfunction. The known high dependency of ASCs on the microenvironment to survive combined to the high diversity of infiltrated tissues implies that ASCs must adapt. Some tissues even within a single clinical autoimmune entity are devoid of infiltration. The latter means that either the tissue is not permissive or ASCs fail to adapt. The origin of infiltrated ASCs is also variable. Indeed, ASCs may be commonly generated in the secondary lymphoid organ draining the autoimmune tissue, and home at the inflammation site under the guidance of specific chemokines. Alternatively, ASCs may be generated locally, when ectopic germinal centers are formed in the autoimmune tissue. Alloimmune tissues with the example of kidney transplantation will also be discussed own to their high similarity with autoimmune tissues. It should also be noted that antibody production is not the only function of ASCs, since cells with regulatory functions have also been described. This article will review all the phenotypic variations indicative of tissue adaptation described so for at the level of ASC-infiltrating auto/alloimmune tissues. The aim is to potentially define tissue-specific molecular targets in ASCs to improve the specificity of future autoimmune treatments. |
format | Online Article Text |
id | pubmed-9989216 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-99892162023-03-08 Heterogeneity of antibody-secreting cells infiltrating autoimmune tissues Giovannini, Diane Belbezier, Aude Baillet, Athan Bouillet, Laurence Kawano, Mitsuhiro Dumestre-Perard, Chantal Clavarino, Giovanna Noble, Johan Pers, Jacques-Olivier Sturm, Nathalie Huard, Bertrand Front Immunol Immunology The humoral response is frequently dysfunctioning in autoimmunity with a frequent rise in total serum immunoglobulins, among which are found autoantibodies that may be pathogenic by themselves and/or propagate the inflammatory reaction. The infiltration of autoimmune tissues by antibody-secreting cells (ASCs) constitutes another dysfunction. The known high dependency of ASCs on the microenvironment to survive combined to the high diversity of infiltrated tissues implies that ASCs must adapt. Some tissues even within a single clinical autoimmune entity are devoid of infiltration. The latter means that either the tissue is not permissive or ASCs fail to adapt. The origin of infiltrated ASCs is also variable. Indeed, ASCs may be commonly generated in the secondary lymphoid organ draining the autoimmune tissue, and home at the inflammation site under the guidance of specific chemokines. Alternatively, ASCs may be generated locally, when ectopic germinal centers are formed in the autoimmune tissue. Alloimmune tissues with the example of kidney transplantation will also be discussed own to their high similarity with autoimmune tissues. It should also be noted that antibody production is not the only function of ASCs, since cells with regulatory functions have also been described. This article will review all the phenotypic variations indicative of tissue adaptation described so for at the level of ASC-infiltrating auto/alloimmune tissues. The aim is to potentially define tissue-specific molecular targets in ASCs to improve the specificity of future autoimmune treatments. Frontiers Media S.A. 2023-02-21 /pmc/articles/PMC9989216/ /pubmed/36895558 http://dx.doi.org/10.3389/fimmu.2023.1111366 Text en Copyright © 2023 Giovannini, Belbezier, Baillet, Bouillet, Kawano, Dumestre-Perard, Clavarino, Noble, Pers, Sturm and Huard https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Giovannini, Diane Belbezier, Aude Baillet, Athan Bouillet, Laurence Kawano, Mitsuhiro Dumestre-Perard, Chantal Clavarino, Giovanna Noble, Johan Pers, Jacques-Olivier Sturm, Nathalie Huard, Bertrand Heterogeneity of antibody-secreting cells infiltrating autoimmune tissues |
title | Heterogeneity of antibody-secreting cells infiltrating autoimmune tissues |
title_full | Heterogeneity of antibody-secreting cells infiltrating autoimmune tissues |
title_fullStr | Heterogeneity of antibody-secreting cells infiltrating autoimmune tissues |
title_full_unstemmed | Heterogeneity of antibody-secreting cells infiltrating autoimmune tissues |
title_short | Heterogeneity of antibody-secreting cells infiltrating autoimmune tissues |
title_sort | heterogeneity of antibody-secreting cells infiltrating autoimmune tissues |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9989216/ https://www.ncbi.nlm.nih.gov/pubmed/36895558 http://dx.doi.org/10.3389/fimmu.2023.1111366 |
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