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Oxidized mC modulates synthetic lethality to PARP inhibitors for the treatment of leukemia

TET2 haploinsufficiency is a driving event in myeloid cancers and is associated with a worse prognosis in patients with acute myeloid leukemia (AML). Enhancing residual TET2 activity using vitamin C increases oxidized 5-methylcytosine (mC) formation and promotes active DNA demethylation via base exc...

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Detalles Bibliográficos
Autores principales:	Brabson, John P., Leesang, Tiffany, Yap, Yoon Sing, Wang, Jingjing, Lam, Minh Q., Fang, Byron, Dolgalev, Igor, Barbieri, Daniela A., Strippoli, Victoria, Bañuelos, Carolina P., Mohammad, Sofia, Lyon, Peter, Chaudhry, Sana, Donich, Dane, Swirski, Anna, Roberts, Evan, Diaz, Ivelisse, Karl, Daniel, Santos, Helena Gomes Dos, Shiekhattar, Ramin, Neel, Benjamin G., Nimer, Stephen D., Verdun, Ramiro E., Bilbao, Daniel, Figueroa, Maria E., Cimmino, Luisa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9989506/ https://www.ncbi.nlm.nih.gov/pubmed/36848231 http://dx.doi.org/10.1016/j.celrep.2023.112027

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