Cationic amphiphilic antihistamines inhibit STAT3 via Ca(2+)-dependent lysosomal H(+) efflux

Commonly used antihistamines and other cationic amphiphilic drugs (CADs) are emerging as putative cancer drugs. Their unique chemical structure enables CADs to accumulate rapidly inside lysosomes, where they increase lysosomal pH, alter lysosomal lipid metabolism, and eventually cause lysosomal memb...

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Detalles Bibliográficos
Autores principales: Liu, Bin, Chen, Ran, Zhang, Yidan, Huang, Jinrong, Luo, Yonglun, Rosthøj, Susanne, Zhao, Chenyang, Jäättelä, Marja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9989825/
https://www.ncbi.nlm.nih.gov/pubmed/36807142
http://dx.doi.org/10.1016/j.celrep.2023.112137

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