Neprilysin-dependent neuropeptide Y cleavage in the liver promotes fibrosis by blocking NPY-receptor 1

Development of liver fibrosis is paralleled by contraction of hepatic stellate cells (HSCs), the main profibrotic hepatic cells. Yet, little is known about the interplay of neprilysin (NEP) and its substrate neuropeptide Y (NPY), a potent enhancer of contraction, in liver fibrosis. We demonstrate th...

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Detalles Bibliográficos
Autores principales: Ortiz, Cristina, Klein, Sabine, Reul, Winfried H., Magdaleno, Fernando, Gröschl, Stefanie, Dietrich, Peter, Schierwagen, Robert, Uschner, Frank E., Torres, Sandra, Hieber, Christoph, Meier, Caroline, Kraus, Nico, Tyc, Olaf, Brol, Maximilian, Zeuzem, Stefan, Welsch, Christoph, Poglitsch, Marco, Hellerbrand, Claus, Alfonso-Prieto, Mercedes, Mira, Fabio, Keller, Ulrich auf dem, Tetzner, Anja, Moore, Andrew, Walther, Thomas, Trebicka, Jonel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9989826/
https://www.ncbi.nlm.nih.gov/pubmed/36729833
http://dx.doi.org/10.1016/j.celrep.2023.112059

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