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Iron-Catalyzed Oxidative α-Amination of Ketones with Primary and Secondary Sulfonamides
[Image: see text] We report the iron-catalyzed α-amination of ketones with sulfonamides. Using an oxidative coupling approach, ketones can be directly coupled with free sulfonamides, without the need for prefunctionalization of either substrate. Primary and secondary sulfonamides are both competent...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9990065/ https://www.ncbi.nlm.nih.gov/pubmed/36811395 http://dx.doi.org/10.1021/acs.joc.3c00210 |
| _version_ | 1784901870501756928 |
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| author | Song, Fubin Park, So Hyun Wu, Christine Strom, Alexandra E. |
| author_facet | Song, Fubin Park, So Hyun Wu, Christine Strom, Alexandra E. |
| author_sort | Song, Fubin |
| collection | PubMed |
| description | [Image: see text] We report the iron-catalyzed α-amination of ketones with sulfonamides. Using an oxidative coupling approach, ketones can be directly coupled with free sulfonamides, without the need for prefunctionalization of either substrate. Primary and secondary sulfonamides are both competent coupling partners, with yields from 55% to 88% for deoxybenzoin-derived substrates. |
| format | Online Article Text |
| id | pubmed-9990065 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | American Chemical Society |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-99900652023-03-08 Iron-Catalyzed Oxidative α-Amination of Ketones with Primary and Secondary Sulfonamides Song, Fubin Park, So Hyun Wu, Christine Strom, Alexandra E. J Org Chem [Image: see text] We report the iron-catalyzed α-amination of ketones with sulfonamides. Using an oxidative coupling approach, ketones can be directly coupled with free sulfonamides, without the need for prefunctionalization of either substrate. Primary and secondary sulfonamides are both competent coupling partners, with yields from 55% to 88% for deoxybenzoin-derived substrates. American Chemical Society 2023-02-22 /pmc/articles/PMC9990065/ /pubmed/36811395 http://dx.doi.org/10.1021/acs.joc.3c00210 Text en © 2023 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Song, Fubin Park, So Hyun Wu, Christine Strom, Alexandra E. Iron-Catalyzed Oxidative α-Amination of Ketones with Primary and Secondary Sulfonamides |
| title | Iron-Catalyzed Oxidative
α-Amination
of Ketones with Primary and Secondary Sulfonamides |
| title_full | Iron-Catalyzed Oxidative
α-Amination
of Ketones with Primary and Secondary Sulfonamides |
| title_fullStr | Iron-Catalyzed Oxidative
α-Amination
of Ketones with Primary and Secondary Sulfonamides |
| title_full_unstemmed | Iron-Catalyzed Oxidative
α-Amination
of Ketones with Primary and Secondary Sulfonamides |
| title_short | Iron-Catalyzed Oxidative
α-Amination
of Ketones with Primary and Secondary Sulfonamides |
| title_sort | iron-catalyzed oxidative
α-amination
of ketones with primary and secondary sulfonamides |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9990065/ https://www.ncbi.nlm.nih.gov/pubmed/36811395 http://dx.doi.org/10.1021/acs.joc.3c00210 |
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