Cargando…

Avidity engineering of human heavy-chain-only antibodies mitigates neutralization resistance of SARS-CoV-2 variants

Emerging SARS-CoV-2 variants have accrued mutations within the spike protein rendering most therapeutic monoclonal antibodies against COVID-19 ineffective. Hence there is an unmet need for broad-spectrum mAb treatments for COVID-19 that are more resistant to antigenically drifted SARS-CoV-2 variants...

Descripción completa

Detalles Bibliográficos
Autores principales:	Du, Wenjuan, Janssens, Rick, Mykytyn, Anna Z., Li, Wentao, Drabek, Dubravka, van Haperen, Rien, Chatziandreou, Marianthi, Rissmann, Melanie, van der Lee, Joline, van Dortmondt, Melissa, Martin, Itziar Serna, van Kuppeveld, Frank J. M., Hurdiss, Daniel L., Haagmans, Bart L., Grosveld, Frank, Bosch, Berend-Jan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9990171/ https://www.ncbi.nlm.nih.gov/pubmed/36895554 http://dx.doi.org/10.3389/fimmu.2023.1111385

Ejemplares similares

Publisher Correction: A human monoclonal antibody blocking SARS-CoV-2 infection
por: Wang, Chunyan, et al.
Publicado: (2020)

A human monoclonal antibody blocking SARS-CoV-2 infection
por: Wang, Chunyan, et al.
Publicado: (2020)

A conserved immunogenic and vulnerable site on the coronavirus spike protein delineated by cross-reactive monoclonal antibodies
por: Wang, Chunyan, et al.
Publicado: (2021)

Antigenic structure of the human coronavirus OC43 spike reveals exposed and occluded neutralizing epitopes
por: Wang, Chunyan, et al.
Publicado: (2022)

Towards a solution to MERS: protective human monoclonal antibodies targeting different domains and functions of the MERS-coronavirus spike glycoprotein
por: Widjaja, Ivy, et al.
Publicado: (2019)

An ACE2-blocking antibody confers broad neutralization and protection against Omicron and other SARS-CoV-2 variants of concern
por: Du, Wenjuan, et al.
Publicado: (2022)

An anti-CTLA-4 heavy chain–only antibody with enhanced T(reg) depletion shows excellent preclinical efficacy and safety profile
por: Gan, Xin, et al.
Publicado: (2022)

Elevated Expression of Phospholipid Transfer Protein in Bone Marrow Derived Cells Causes Atherosclerosis
por: van Haperen, Rien, et al.
Publicado: (2008)

Structural insights into the cross-neutralization of SARS-CoV and SARS-CoV-2 by the human monoclonal antibody 47D11
por: Fedry, Juliette, et al.
Publicado: (2021)

Expression Cloning and Production of Human Heavy-Chain-Only Antibodies from Murine Transgenic Plasma Cells
por: Drabek, Dubravka, et al.
Publicado: (2016)

Serological Screening for Coronavirus Infections in Cats
por: Zhao, Shan, et al.
Publicado: (2019)

Cellular entry of the porcine epidemic diarrhea virus
por: Li, Wentao, et al.
Publicado: (2016)

Aminopeptidase N is not required for porcine epidemic diarrhea virus cell entry
por: Li, Wentao, et al.
Publicado: (2017)

WNT/beta-catenin signalling interrupts a senescence-induction cascade in human mesenchymal stem cells that restricts their expansion
por: Lehmann, Johannes, et al.
Publicado: (2022)

A Dual Reporter Mouse Model of the Human β-Globin Locus: Applications and Limitations
por: Papadopoulos, Petros, et al.
Publicado: (2012)

Coronavirus Cell Entry Occurs through the Endo-/Lysosomal Pathway in a Proteolysis-Dependent Manner
por: Burkard, Christine, et al.
Publicado: (2014)

Development and Validation of a S1 Protein-Based ELISA for the Specific Detection of Antibodies against Equine Coronavirus
por: Zhao, Shan, et al.
Publicado: (2019)

SARS-CoV-2 nucleocapsid protein inhibits the PKR-mediated integrated stress response through RNA-binding domain N2b
por: Aloise, Chiara, et al.
Publicado: (2023)

Moral Challenges of Nurses and Volunteers in Dutch Palliative Care. A Qualitative Study
por: van den Bosch, Geerke, et al.
Publicado: (2022)

Manipulation of the Porcine Epidemic Diarrhea Virus Genome Using Targeted RNA Recombination
por: Li, Chunhua, et al.
Publicado: (2013)

Serologic Screening of Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Cats and Dogs during First Coronavirus Disease Wave, the Netherlands
por: Zhao, Shan, et al.
Publicado: (2021)

Identification of the Cell-Surface Protease ADAM9 as an Entry Factor for Encephalomyocarditis Virus
por: Baggen, Jim, et al.
Publicado: (2019)

Glycosylated extracellular mucin domains protect against SARS-CoV-2 infection at the respiratory surface
por: Chatterjee, Maitrayee, et al.
Publicado: (2023)

Antibody avidity, persistence, and response to antigen recall: comparison of vaccine adjuvants
por: Budroni, Sonia, et al.
Publicado: (2021)

Cryo-EM structure of coronavirus-HKU1 haemagglutinin esterase reveals architectural changes arising from prolonged circulation in humans
por: Hurdiss, Daniel L., et al.
Publicado: (2020)

Dissecting Virus Entry: Replication-Independent Analysis of Virus Binding, Internalization, and Penetration Using Minimal Complementation of β-Galactosidase
por: Burkard, Christine, et al.
Publicado: (2014)

Response of FDG avid pelvic bone marrow to concurrent chemoradiation for anal cancer
por: Robinson, Maxwell, et al.
Publicado: (2020)

Chimeric camel/human heavy-chain antibodies protect against MERS-CoV infection
por: Stalin Raj, V., et al.
Publicado: (2018)

Protective efficacy of an RBD-based Middle East respiratory syndrome coronavirus (MERS-CoV) particle vaccine in llamas
por: Rodon, Jordi, et al.
Publicado: (2022)

Overexpression of endothelial nitric oxide synthase suppresses features of allergic asthma in mice
por: Broeke, Robert Ten, et al.
Publicado: (2006)

Avid Editing
por: Kauffmann, Sam, et al.
Publicado: (2017)

An Avid Imitator
por: Farmakiotis, Dimitrios, et al.
Publicado: (2016)

Live-cell imaging of chromatin contacts opens a new window into chromatin dynamics
por: van Staalduinen, Jente, et al.
Publicado: (2023)

Editing with Avid Media Composer 5: the official Avid guide.
por: Kennedy, Ashley
Publicado: (2010)

Avidity Mechanism of Dendrimer–Folic Acid Conjugates
por: van Dongen, Mallory A., et al.
Publicado: (2014)

Nature After the Genome Sarah Parry and John Dupré (eds.) Oxford: Blackwell Publishing, 2011
por: van der Hout, Sanne, et al.
Publicado: (2010)

The 2(nd) sialic acid-binding site of influenza A virus neuraminidase is an important determinant of the hemagglutinin-neuraminidase-receptor balance
por: Du, Wenjuan, et al.
Publicado: (2019)

Spatiotemporal endothelial cell – pericyte association in tumors as shown by high resolution 4D intravital imaging
por: Seynhaeve, Ann L. B., et al.
Publicado: (2018)

Membrane ectopeptidases targeted by human coronaviruses
por: Bosch, Berend Jan, et al.
Publicado: (2014)

Spiking the MERS-coronavirus receptor
por: Bosch, Berend Jan, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_b2dunkp2petu28ka71k1skvena