The epigenetic regulatory mechanism of PIWI/piRNAs in human cancers

PIWI proteins have a strong correlation with PIWI-interacting RNAs (piRNAs), which are significant in development and reproduction of organisms. Recently, emerging evidences have indicated that apart from the reproductive function, PIWI/piRNAs with abnormal expression, also involve greatly in variet...

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Autores principales: Zhang, Qun, Zhu, Yazhi, Cao, Xinyu, Tan, Wenhui, Yu, Jianglong, Lu, Yaqiong, Kang, Ran, Wang, Xiaolan, Li, Ermao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9990219/
https://www.ncbi.nlm.nih.gov/pubmed/36882835
http://dx.doi.org/10.1186/s12943-023-01749-3
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author Zhang, Qun
Zhu, Yazhi
Cao, Xinyu
Tan, Wenhui
Yu, Jianglong
Lu, Yaqiong
Kang, Ran
Wang, Xiaolan
Li, Ermao
author_facet Zhang, Qun
Zhu, Yazhi
Cao, Xinyu
Tan, Wenhui
Yu, Jianglong
Lu, Yaqiong
Kang, Ran
Wang, Xiaolan
Li, Ermao
author_sort Zhang, Qun
collection PubMed
description PIWI proteins have a strong correlation with PIWI-interacting RNAs (piRNAs), which are significant in development and reproduction of organisms. Recently, emerging evidences have indicated that apart from the reproductive function, PIWI/piRNAs with abnormal expression, also involve greatly in varieties of human cancers. Moreover, human PIWI proteins are usually expressed only in germ cells and hardly in somatic cells, so the abnormal expression of PIWI proteins in different types of cancer offer a promising opportunity for precision medicine. In this review, we discussed current researches about the biogenesis of piRNA, its epigenetic regulatory mechanisms in human cancers, such as N6-methyladenosine (m(6)A) methylation, histone modifications, DNA methylation and RNA interference, providing novel insights into the markers for clinical diagnosis, treatment and prognosis in human cancers.
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spelling pubmed-99902192023-03-08 The epigenetic regulatory mechanism of PIWI/piRNAs in human cancers Zhang, Qun Zhu, Yazhi Cao, Xinyu Tan, Wenhui Yu, Jianglong Lu, Yaqiong Kang, Ran Wang, Xiaolan Li, Ermao Mol Cancer Review PIWI proteins have a strong correlation with PIWI-interacting RNAs (piRNAs), which are significant in development and reproduction of organisms. Recently, emerging evidences have indicated that apart from the reproductive function, PIWI/piRNAs with abnormal expression, also involve greatly in varieties of human cancers. Moreover, human PIWI proteins are usually expressed only in germ cells and hardly in somatic cells, so the abnormal expression of PIWI proteins in different types of cancer offer a promising opportunity for precision medicine. In this review, we discussed current researches about the biogenesis of piRNA, its epigenetic regulatory mechanisms in human cancers, such as N6-methyladenosine (m(6)A) methylation, histone modifications, DNA methylation and RNA interference, providing novel insights into the markers for clinical diagnosis, treatment and prognosis in human cancers. BioMed Central 2023-03-07 /pmc/articles/PMC9990219/ /pubmed/36882835 http://dx.doi.org/10.1186/s12943-023-01749-3 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Zhang, Qun
Zhu, Yazhi
Cao, Xinyu
Tan, Wenhui
Yu, Jianglong
Lu, Yaqiong
Kang, Ran
Wang, Xiaolan
Li, Ermao
The epigenetic regulatory mechanism of PIWI/piRNAs in human cancers
title The epigenetic regulatory mechanism of PIWI/piRNAs in human cancers
title_full The epigenetic regulatory mechanism of PIWI/piRNAs in human cancers
title_fullStr The epigenetic regulatory mechanism of PIWI/piRNAs in human cancers
title_full_unstemmed The epigenetic regulatory mechanism of PIWI/piRNAs in human cancers
title_short The epigenetic regulatory mechanism of PIWI/piRNAs in human cancers
title_sort epigenetic regulatory mechanism of piwi/pirnas in human cancers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9990219/
https://www.ncbi.nlm.nih.gov/pubmed/36882835
http://dx.doi.org/10.1186/s12943-023-01749-3
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