Multi-ancestry phenome-wide association of complement component 4 variation with psychiatric and brain phenotypes in youth

BACKGROUND: Increased expression of the complement component 4A (C4A) gene is associated with a greater lifetime risk of schizophrenia. In the brain, C4A is involved in synaptic pruning; yet, it remains unclear the extent to which upregulation of C4A alters brain development or is associated with th...

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Detalles Bibliográficos
Autores principales: Hernandez, Leanna M., Kim, Minsoo, Zhang, Pan, Bethlehem, Richard A. I., Hoftman, Gil, Loughnan, Robert, Smith, Diana, Bookheimer, Susan Y., Fan, Chun Chieh, Bearden, Carrie E., Thompson, Wesley K., Gandal, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9990244/
https://www.ncbi.nlm.nih.gov/pubmed/36882872
http://dx.doi.org/10.1186/s13059-023-02878-0

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