Cargando…

Exercise activates Sirt1-mediated Drp1 acetylation and inhibits hepatocyte apoptosis to improve nonalcoholic fatty liver disease

PURPOSE: Aerobic exercise has shown beneficial effects in the prevention and treatment of non-alcoholic fatty liver disease (NAFLD). Nevertheless, the regulatory mechanism is not turely clear. Therefore, we aim to clarify the possible mechanism by investigating the effects of aerobic exercise on NAF...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hu, Zongqiang, Zhang, Hongyu, Wang, Yiting, Li, Boyi, Liu, Kaiyu, Ran, Jianghua, Li, Li
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9990292/ https://www.ncbi.nlm.nih.gov/pubmed/36882837 http://dx.doi.org/10.1186/s12944-023-01798-z

Ejemplares similares

Inhibition of Drp1 protects against senecionine-induced mitochondria-mediated apoptosis in primary hepatocytes and in mice
por: Yang, Xiao, et al.
Publicado: (2017)

SIRT2 regulates mitochondrial dynamics and reprogramming via MEK1-ERK-DRP1 and AKT1-DRP1 axes
por: Cha, Young, et al.
Publicado: (2021)

Cooperative effects of SIRT1 and SIRT2 on APP acetylation
por: Li, Na, et al.
Publicado: (2023)

LB100 ameliorates nonalcoholic fatty liver disease via the AMPK/Sirt1 pathway
por: Chen, Xue-Yang, et al.
Publicado: (2019)

SIRT1 Activator E1231 Alleviates Nonalcoholic Fatty Liver Disease by Regulating Lipid Metabolism
por: Han, Jiangxue, et al.
Publicado: (2023)

SIRT1 as a potential therapeutic target for treatment of nonalcoholic fatty liver disease
por: Colak, Yasar, et al.
Publicado: (2011)

Hepatocyte apoptosis is tumor promoting in murine nonalcoholic steatohepatitis
por: Hirsova, Petra, et al.
Publicado: (2020)

Drp1 and RB interaction to mediate mitochondria-dependent necroptosis induced by cadmium in hepatocytes
por: Zhang, Shili, et al.
Publicado: (2019)

Huperzine A attenuates nonalcoholic fatty liver disease by regulating hepatocyte senescence and apoptosis: an in vitro study
por: Hu, Xiao-na, et al.
Publicado: (2018)

Hepatoprotective effect of calculus bovis sativus on nonalcoholic fatty liver disease in mice by inhibiting oxidative stress and apoptosis of hepatocytes
por: He, Wenxi, et al.
Publicado: (2017)

Melatonin prevents Drp1‐mediated mitochondrial fission in diabetic hearts through SIRT1‐PGC1α pathway
por: Ding, Mingge, et al.
Publicado: (2018)

Abnormal CD44 activation of hepatocytes with nonalcoholic fatty accumulation in rat hepatocarcinogenesis
por: Fang, Miao, et al.
Publicado: (2020)

Ets-1 deficiency alleviates nonalcoholic steatohepatitis via weakening TGF-β1 signaling-mediated hepatocyte apoptosis
por: Liu, Dechen, et al.
Publicado: (2019)

Foxa1 Reduces Lipid Accumulation in Human Hepatocytes and Is Down-Regulated in Nonalcoholic Fatty Liver
por: Moya, Marta, et al.
Publicado: (2012)

Elucidation of SIRT-1/PGC-1α-associated mitochondrial dysfunction and autophagy in nonalcoholic fatty liver disease
por: Jiang, Yan, et al.
Publicado: (2021)

Toyocamycin attenuates free fatty acid-induced hepatic steatosis and apoptosis in cultured hepatocytes and ameliorates nonalcoholic fatty liver disease in mice
por: Takahara, Ikuko, et al.
Publicado: (2017)

BH3 mimetics induce apoptosis independent of DRP-1 in melanoma
por: Mukherjee, Nabanita, et al.
Publicado: (2018)

DRP-1-mediated apoptosis induces muscle degeneration in dystrophin mutants
por: Scholtes, Charlotte, et al.
Publicado: (2018)

DRP1 interacts directly with BAX to induce its activation and apoptosis
por: Jenner, Andreas, et al.
Publicado: (2022)

Correction: Toyocamycin attenuates free fatty acid-induced hepatic steatosis and apoptosis in cultured hepatocytes and ameliorates nonalcoholic fatty liver disease in mice
por: Takahara, Ikuko, et al.
Publicado: (2020)

Altered microRNA-9 Expression Level is Directly Correlated with Pathogenesis of Nonalcoholic Fatty Liver Disease by Targeting Onecut2 and SIRT1
por: Ao, Ran, et al.
Publicado: (2016)

Progress in Nonalcoholic Fatty Liver Disease: SIRT Family Regulates Mitochondrial Biogenesis
por: Zeng, Chuanfei, et al.
Publicado: (2022)

Mitochondrial translocation and interaction of cofilin and Drp1 are required for erucin-induced mitochondrial fission and apoptosis
por: Li, Guobing, et al.
Publicado: (2014)

Deregulation of Mitochondria-Shaping Proteins Opa-1 and Drp-1 in Manganese-Induced Apoptosis
por: Alaimo, Agustina, et al.
Publicado: (2014)

Lipocalin‐2 Protects Against Diet‐Induced Nonalcoholic Fatty Liver Disease by Targeting Hepatocytes
por: Xu, Yanyong, et al.
Publicado: (2019)

Sirt6 deficiency contributes to mitochondrial fission and oxidative damage in podocytes via ROCK1‐Drp1 signalling pathway
por: Chen, Zhaowei, et al.
Publicado: (2022)

DRP-1 is required for BH3 mimetic-mediated mitochondrial fragmentation and apoptosis
por: Milani, Mateus, et al.
Publicado: (2017)

PGC-1α Promotes Ureagenesis in Mouse Periportal Hepatocytes through SIRT3 and SIRT5 in Response to Glucagon
por: Li, Lulu, et al.
Publicado: (2016)

Nonalcoholic Lipid Accumulation and Hepatocyte Malignant Transformation
por: Gu, Juanjuan, et al.
Publicado: (2016)

Modified rougan decoction attenuates hepatocyte apoptosis through ameliorating mitochondrial dysfunction by upregulated SIRT1/PGC-1α signaling pathway
por: Wang, Wenjia, et al.
Publicado: (2023)

Dexmedetomidine hydrochloride inhibits hepatocyte apoptosis and inflammation by activating the lncRNA TUG1/miR-194/SIRT1 signaling pathway
por: Gu, Xiao-Xia, et al.
Publicado: (2021)

MIEF1/2 function as adaptors to recruit Drp1 to mitochondria and regulate the association of Drp1 with Mff
por: Yu, Rong, et al.
Publicado: (2017)

Sirt1 protects neural stem cells from apoptosis by decreasing acetylation of histone 3K9
por: Jian, Chongdong, et al.
Publicado: (2018)

Dietary Blueberry and Bifidobacteria Attenuate Nonalcoholic Fatty Liver Disease in Rats by Affecting SIRT1-Mediated Signaling Pathway
por: Ren, Tingting, et al.
Publicado: (2014)

Hepatocyte Smoothened Activity Controls Susceptibility to Insulin Resistance and Nonalcoholic Fatty Liver Disease
por: Chen, Tianyi, et al.
Publicado: (2022)

SIRT1 mediates the inhibitory effect of Dapagliflozin on EndMT by inhibiting the acetylation of endothelium Notch1
por: Wang, Weijie, et al.
Publicado: (2023)

Salidroside Inhibits HMGB1 Acetylation and Release through Upregulation of SirT1 during Inflammation
por: Qi, Zhilin, et al.
Publicado: (2017)

Nurr1 Promotes Lung Cancer Apoptosis Via Enhancing Mitochondrial Stress and p53-Drp1 Pathway
por: Zhao, Shu, et al.
Publicado: (2019)

Dynamin-related protein Drp1 is required for Bax translocation to mitochondria in response to irradiation-induced apoptosis
por: Wang, Ping, et al.
Publicado: (2015)

PDI-mediated S-nitrosylation of DRP1 facilitates DRP1-S616 phosphorylation and mitochondrial fission in CA1 neurons
por: Lee, Duk-shin, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_a1c3h6cqdj52vkjsg712u3nldh