Microglia specific deletion of miR-155 in Alzheimer’s disease mouse models reduces amyloid-β pathology but causes hyperexcitability and seizures

Alzheimer’s Disease (AD) is characterized by the accumulation of extracellular amyloid-β (Aβ) as well as CNS and systemic inflammation. Microglia, the myeloid cells resident in the CNS, use microRNAs to rapidly respond to inflammatory signals. MicroRNAs (miRNAs) modulate inflammatory responses in mi...

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Detalles Bibliográficos
Autores principales: Aloi, Macarena S., Prater, Katherine E., Sánchez, Raymond E. A., Beck, Asad, Pathan, Jasmine L., Davidson, Stephanie, Wilson, Angela, Keene, C. Dirk, de la Iglesia, Horacio, Jayadev, Suman, Garden, Gwenn A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9990295/
https://www.ncbi.nlm.nih.gov/pubmed/36879321
http://dx.doi.org/10.1186/s12974-023-02745-6

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