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Prevalence and persistence of Neisseria meningitidis carriage in Swedish university students
The bacterium Neisseria meningitidis causes life-threatening disease worldwide, typically with a clinical presentation of sepsis or meningitis, but can be carried asymptomatically as part of the normal human oropharyngeal microbiota. The aim of this study was to examine N. meningitidis carriage with...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cambridge University Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9990396/ https://www.ncbi.nlm.nih.gov/pubmed/36775828 http://dx.doi.org/10.1017/S0950268823000018 |
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author | Olof, Säll Lorraine, Eriksson Berhane A., Idosa Alexander, Persson Anders, Magnuson Sara, Thulin Hedberg Martin, Sundqvist Per, Olcén Hans, Fredlund Bianca, Stenmark Eva, Särndahl Paula, Mölling Susanne, Jacobsson |
author_facet | Olof, Säll Lorraine, Eriksson Berhane A., Idosa Alexander, Persson Anders, Magnuson Sara, Thulin Hedberg Martin, Sundqvist Per, Olcén Hans, Fredlund Bianca, Stenmark Eva, Särndahl Paula, Mölling Susanne, Jacobsson |
author_sort | Olof, Säll |
collection | PubMed |
description | The bacterium Neisseria meningitidis causes life-threatening disease worldwide, typically with a clinical presentation of sepsis or meningitis, but can be carried asymptomatically as part of the normal human oropharyngeal microbiota. The aim of this study was to examine N. meningitidis carriage with regard to prevalence, risk factors for carriage, distribution of meningococcal lineages and persistence of meningococcal carriage. Throat samples and data from a self-reported questionnaire were obtained from 2744 university students (median age: 23 years) at a university in Sweden on four occasions during a 12-month period. Meningococcal isolates were characterised using whole-genome sequencing. The carriage rate among the students was 9.1% (319/3488; 95% CI 8.2–10.1). Factors associated with higher carriage rate were age ≤22 years, previous tonsillectomy, cigarette smoking, drinking alcohol and attending parties, pubs and clubs. Female gender and sharing a household with children aged 0–9 years were associated with lower carriage. The most frequent genogroups were capsule null locus (cnl), group B and group Y and the most commonly identified clonal complexes (cc) were cc198 and cc23. Persistent carriage with the same meningococcal strain for 12 months was observed in two students. Follow-up times exceeding 12 months are recommended for future studies investigating long-term carriage of N. meningitidis. |
format | Online Article Text |
id | pubmed-9990396 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cambridge University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-99903962023-03-08 Prevalence and persistence of Neisseria meningitidis carriage in Swedish university students Olof, Säll Lorraine, Eriksson Berhane A., Idosa Alexander, Persson Anders, Magnuson Sara, Thulin Hedberg Martin, Sundqvist Per, Olcén Hans, Fredlund Bianca, Stenmark Eva, Särndahl Paula, Mölling Susanne, Jacobsson Epidemiol Infect Original Paper The bacterium Neisseria meningitidis causes life-threatening disease worldwide, typically with a clinical presentation of sepsis or meningitis, but can be carried asymptomatically as part of the normal human oropharyngeal microbiota. The aim of this study was to examine N. meningitidis carriage with regard to prevalence, risk factors for carriage, distribution of meningococcal lineages and persistence of meningococcal carriage. Throat samples and data from a self-reported questionnaire were obtained from 2744 university students (median age: 23 years) at a university in Sweden on four occasions during a 12-month period. Meningococcal isolates were characterised using whole-genome sequencing. The carriage rate among the students was 9.1% (319/3488; 95% CI 8.2–10.1). Factors associated with higher carriage rate were age ≤22 years, previous tonsillectomy, cigarette smoking, drinking alcohol and attending parties, pubs and clubs. Female gender and sharing a household with children aged 0–9 years were associated with lower carriage. The most frequent genogroups were capsule null locus (cnl), group B and group Y and the most commonly identified clonal complexes (cc) were cc198 and cc23. Persistent carriage with the same meningococcal strain for 12 months was observed in two students. Follow-up times exceeding 12 months are recommended for future studies investigating long-term carriage of N. meningitidis. Cambridge University Press 2023-02-13 /pmc/articles/PMC9990396/ /pubmed/36775828 http://dx.doi.org/10.1017/S0950268823000018 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited. |
spellingShingle | Original Paper Olof, Säll Lorraine, Eriksson Berhane A., Idosa Alexander, Persson Anders, Magnuson Sara, Thulin Hedberg Martin, Sundqvist Per, Olcén Hans, Fredlund Bianca, Stenmark Eva, Särndahl Paula, Mölling Susanne, Jacobsson Prevalence and persistence of Neisseria meningitidis carriage in Swedish university students |
title | Prevalence and persistence of Neisseria meningitidis carriage in Swedish university students |
title_full | Prevalence and persistence of Neisseria meningitidis carriage in Swedish university students |
title_fullStr | Prevalence and persistence of Neisseria meningitidis carriage in Swedish university students |
title_full_unstemmed | Prevalence and persistence of Neisseria meningitidis carriage in Swedish university students |
title_short | Prevalence and persistence of Neisseria meningitidis carriage in Swedish university students |
title_sort | prevalence and persistence of neisseria meningitidis carriage in swedish university students |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9990396/ https://www.ncbi.nlm.nih.gov/pubmed/36775828 http://dx.doi.org/10.1017/S0950268823000018 |
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