Cargando…

An approximate line attractor in the hypothalamus encodes an aggressive state

The hypothalamus regulates innate social behaviors, including mating and aggression. These behaviors can be evoked by optogenetic stimulation of specific neuronal subpopulations within MPOA and VMHvl, respectively. Here we perform dynamical systems modeling of population neuronal activity in these n...

Descripción completa

Detalles Bibliográficos
Autores principales: Nair, Aditya, Karigo, Tomomi, Yang, Bin, Ganguli, Surya, Schnitzer, Mark J., Linderman, Scott W., Anderson, David J., Kennedy, Ann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9990527/
https://www.ncbi.nlm.nih.gov/pubmed/36608653
http://dx.doi.org/10.1016/j.cell.2022.11.027
_version_ 1784901951054413824
author Nair, Aditya
Karigo, Tomomi
Yang, Bin
Ganguli, Surya
Schnitzer, Mark J.
Linderman, Scott W.
Anderson, David J.
Kennedy, Ann
author_facet Nair, Aditya
Karigo, Tomomi
Yang, Bin
Ganguli, Surya
Schnitzer, Mark J.
Linderman, Scott W.
Anderson, David J.
Kennedy, Ann
author_sort Nair, Aditya
collection PubMed
description The hypothalamus regulates innate social behaviors, including mating and aggression. These behaviors can be evoked by optogenetic stimulation of specific neuronal subpopulations within MPOA and VMHvl, respectively. Here we perform dynamical systems modeling of population neuronal activity in these nuclei during social behaviors. In VMHvl, unsupervised analysis identified a dominant dimension of neural activity with a large time constant (>50s), generating an approximate line attractor in neural state space. Progression of the neural trajectory along this attractor was correlated with an escalation of agonistic behavior, suggesting that it may encode a scalable state of aggressiveness. Consistent with this, individual differences in the magnitude of the attractor time constant were strongly correlated with differences in aggressiveness. In contrast, line attractors were not observed in MPOA during mating; instead, neurons with fast dynamics were tuned to specific actions. Thus, different hypothalamic nuclei employ distinct neural population codes to represent similar social behaviors.
format Online
Article
Text
id pubmed-9990527
institution National Center for Biotechnology Information
language English
publishDate 2023
record_format MEDLINE/PubMed
spelling pubmed-99905272023-03-07 An approximate line attractor in the hypothalamus encodes an aggressive state Nair, Aditya Karigo, Tomomi Yang, Bin Ganguli, Surya Schnitzer, Mark J. Linderman, Scott W. Anderson, David J. Kennedy, Ann Cell Article The hypothalamus regulates innate social behaviors, including mating and aggression. These behaviors can be evoked by optogenetic stimulation of specific neuronal subpopulations within MPOA and VMHvl, respectively. Here we perform dynamical systems modeling of population neuronal activity in these nuclei during social behaviors. In VMHvl, unsupervised analysis identified a dominant dimension of neural activity with a large time constant (>50s), generating an approximate line attractor in neural state space. Progression of the neural trajectory along this attractor was correlated with an escalation of agonistic behavior, suggesting that it may encode a scalable state of aggressiveness. Consistent with this, individual differences in the magnitude of the attractor time constant were strongly correlated with differences in aggressiveness. In contrast, line attractors were not observed in MPOA during mating; instead, neurons with fast dynamics were tuned to specific actions. Thus, different hypothalamic nuclei employ distinct neural population codes to represent similar social behaviors. 2023-01-05 /pmc/articles/PMC9990527/ /pubmed/36608653 http://dx.doi.org/10.1016/j.cell.2022.11.027 Text en https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License, which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use.
spellingShingle Article
Nair, Aditya
Karigo, Tomomi
Yang, Bin
Ganguli, Surya
Schnitzer, Mark J.
Linderman, Scott W.
Anderson, David J.
Kennedy, Ann
An approximate line attractor in the hypothalamus encodes an aggressive state
title An approximate line attractor in the hypothalamus encodes an aggressive state
title_full An approximate line attractor in the hypothalamus encodes an aggressive state
title_fullStr An approximate line attractor in the hypothalamus encodes an aggressive state
title_full_unstemmed An approximate line attractor in the hypothalamus encodes an aggressive state
title_short An approximate line attractor in the hypothalamus encodes an aggressive state
title_sort approximate line attractor in the hypothalamus encodes an aggressive state
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9990527/
https://www.ncbi.nlm.nih.gov/pubmed/36608653
http://dx.doi.org/10.1016/j.cell.2022.11.027
work_keys_str_mv AT nairaditya anapproximatelineattractorinthehypothalamusencodesanaggressivestate
AT karigotomomi anapproximatelineattractorinthehypothalamusencodesanaggressivestate
AT yangbin anapproximatelineattractorinthehypothalamusencodesanaggressivestate
AT gangulisurya anapproximatelineattractorinthehypothalamusencodesanaggressivestate
AT schnitzermarkj anapproximatelineattractorinthehypothalamusencodesanaggressivestate
AT lindermanscottw anapproximatelineattractorinthehypothalamusencodesanaggressivestate
AT andersondavidj anapproximatelineattractorinthehypothalamusencodesanaggressivestate
AT kennedyann anapproximatelineattractorinthehypothalamusencodesanaggressivestate
AT nairaditya approximatelineattractorinthehypothalamusencodesanaggressivestate
AT karigotomomi approximatelineattractorinthehypothalamusencodesanaggressivestate
AT yangbin approximatelineattractorinthehypothalamusencodesanaggressivestate
AT gangulisurya approximatelineattractorinthehypothalamusencodesanaggressivestate
AT schnitzermarkj approximatelineattractorinthehypothalamusencodesanaggressivestate
AT lindermanscottw approximatelineattractorinthehypothalamusencodesanaggressivestate
AT andersondavidj approximatelineattractorinthehypothalamusencodesanaggressivestate
AT kennedyann approximatelineattractorinthehypothalamusencodesanaggressivestate