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Remdesivir-induced conduction abnormalities: A molecular model-based explanation

Purpose: Remdesivir use in COVID-19 is associated with cardiac conduction abnormalities from unclear mechanisms. A proposed mechanism is the bioaccumulation of the intermediate metabolite GS-441524 resulting in exogenous activation of cardiac adenosine A1 due to the structural similarity between ade...

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Detalles Bibliográficos
Autores principales:	Kingsley, Ryan, Rohlman, Christopher, Otto, Ashley, Chaudhary, Rahul, Phelan, David, Kirchoff, Robert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Science archive
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9990623/ https://www.ncbi.nlm.nih.gov/pubmed/36942295 http://dx.doi.org/10.3389/jpps.2023.11208

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