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Ambra1 modulates the tumor immune microenvironment and response to PD-1 blockade in melanoma
BACKGROUND: Loss of Ambra1 (autophagy and beclin 1 regulator 1), a multifunctional scaffold protein, promotes the formation of nevi and contributes to several phases of melanoma development. The suppressive functions of Ambra1 in melanoma are mediated by negative regulation of cell proliferation and...
Autores principales: | Frias, Alex, Di Leo, Luca, Antoranz, Asier, Nazerai, Loulieta, Carretta, Marco, Bodemeyer, Valérie, Pagliuca, Chiara, Dahl, Christina, Claps, Giuseppina, Mandelli, Giulio Eugenio, Andhari, Madhavi Dipak, Pacheco, Maria Pires, Sauter, Thomas, Robert, Caroline, Guldberg, Per, Madsen, Daniel Hargbøl, Cecconi, Francesco, Bosisio, Francesca Maria, De Zio, Daniela |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9990656/ https://www.ncbi.nlm.nih.gov/pubmed/36868570 http://dx.doi.org/10.1136/jitc-2022-006389 |
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