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Soft-Tissue Anaplastic Lymphoma Kinase-Positive Anaplastic Large Cell Lymphoma in a Child Unmasked by COVID-19

Anaplastic large cell lymphoma (ALCL) is children’s most common mature T-cell neoplasm. The majority is positive for anaplastic lymphoma kinase (ALK). Initial presentation as a soft-tissue pelvic mass without nodal involvement is rare and can be easily misdiagnosed. We report a case of a 12-year-old...

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Autores principales: Lozano-Jaramillo, Diego Alberto, Millan-Arreola, Esperanza, Esquer-Cota, Oscar Omar, Lozano-Garcia, Jesus Manuel, Valenzuela-Espinoza, Miguel Alfonso
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elmer Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9990711/
https://www.ncbi.nlm.nih.gov/pubmed/36895288
http://dx.doi.org/10.14740/jh1081
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author Lozano-Jaramillo, Diego Alberto
Millan-Arreola, Esperanza
Esquer-Cota, Oscar Omar
Lozano-Garcia, Jesus Manuel
Valenzuela-Espinoza, Miguel Alfonso
author_facet Lozano-Jaramillo, Diego Alberto
Millan-Arreola, Esperanza
Esquer-Cota, Oscar Omar
Lozano-Garcia, Jesus Manuel
Valenzuela-Espinoza, Miguel Alfonso
author_sort Lozano-Jaramillo, Diego Alberto
collection PubMed
description Anaplastic large cell lymphoma (ALCL) is children’s most common mature T-cell neoplasm. The majority is positive for anaplastic lymphoma kinase (ALK). Initial presentation as a soft-tissue pelvic mass without nodal involvement is rare and can be easily misdiagnosed. We report a case of a 12-year-old male presenting with pain and movement restriction in the right extremity. Computed tomography (CT) scan revealed a solitary pelvic mass. Initial biopsy examination concluded rhabdomyosarcoma. After developing pediatric multisystemic inflammatory syndrome due to coronavirus disease 2019 (COVID-19), central and peripheral lymph node enlargement appeared. New cervical adenopathy and pelvic mass biopsies were performed. Immunohistochemistry concluded an ALK-positive ALCL with a small-cell pattern. The patient was treated with brentuximab-based chemotherapy and eventually improved. Differential diagnosis of pelvic masses in children and adolescents must include ALCL. An inflammatory trigger may promote the appearance of a typical nodal disease, previously absent. Attention is warranted during histopathological examination to avoid diagnostic errors.
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spelling pubmed-99907112023-03-08 Soft-Tissue Anaplastic Lymphoma Kinase-Positive Anaplastic Large Cell Lymphoma in a Child Unmasked by COVID-19 Lozano-Jaramillo, Diego Alberto Millan-Arreola, Esperanza Esquer-Cota, Oscar Omar Lozano-Garcia, Jesus Manuel Valenzuela-Espinoza, Miguel Alfonso J Hematol Case Report Anaplastic large cell lymphoma (ALCL) is children’s most common mature T-cell neoplasm. The majority is positive for anaplastic lymphoma kinase (ALK). Initial presentation as a soft-tissue pelvic mass without nodal involvement is rare and can be easily misdiagnosed. We report a case of a 12-year-old male presenting with pain and movement restriction in the right extremity. Computed tomography (CT) scan revealed a solitary pelvic mass. Initial biopsy examination concluded rhabdomyosarcoma. After developing pediatric multisystemic inflammatory syndrome due to coronavirus disease 2019 (COVID-19), central and peripheral lymph node enlargement appeared. New cervical adenopathy and pelvic mass biopsies were performed. Immunohistochemistry concluded an ALK-positive ALCL with a small-cell pattern. The patient was treated with brentuximab-based chemotherapy and eventually improved. Differential diagnosis of pelvic masses in children and adolescents must include ALCL. An inflammatory trigger may promote the appearance of a typical nodal disease, previously absent. Attention is warranted during histopathological examination to avoid diagnostic errors. Elmer Press 2023-02 2023-02-25 /pmc/articles/PMC9990711/ /pubmed/36895288 http://dx.doi.org/10.14740/jh1081 Text en Copyright 2023, Lozano-Jaramillo et al. https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution Non-Commercial 4.0 International License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Lozano-Jaramillo, Diego Alberto
Millan-Arreola, Esperanza
Esquer-Cota, Oscar Omar
Lozano-Garcia, Jesus Manuel
Valenzuela-Espinoza, Miguel Alfonso
Soft-Tissue Anaplastic Lymphoma Kinase-Positive Anaplastic Large Cell Lymphoma in a Child Unmasked by COVID-19
title Soft-Tissue Anaplastic Lymphoma Kinase-Positive Anaplastic Large Cell Lymphoma in a Child Unmasked by COVID-19
title_full Soft-Tissue Anaplastic Lymphoma Kinase-Positive Anaplastic Large Cell Lymphoma in a Child Unmasked by COVID-19
title_fullStr Soft-Tissue Anaplastic Lymphoma Kinase-Positive Anaplastic Large Cell Lymphoma in a Child Unmasked by COVID-19
title_full_unstemmed Soft-Tissue Anaplastic Lymphoma Kinase-Positive Anaplastic Large Cell Lymphoma in a Child Unmasked by COVID-19
title_short Soft-Tissue Anaplastic Lymphoma Kinase-Positive Anaplastic Large Cell Lymphoma in a Child Unmasked by COVID-19
title_sort soft-tissue anaplastic lymphoma kinase-positive anaplastic large cell lymphoma in a child unmasked by covid-19
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9990711/
https://www.ncbi.nlm.nih.gov/pubmed/36895288
http://dx.doi.org/10.14740/jh1081
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