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Soft-Tissue Anaplastic Lymphoma Kinase-Positive Anaplastic Large Cell Lymphoma in a Child Unmasked by COVID-19
Anaplastic large cell lymphoma (ALCL) is children’s most common mature T-cell neoplasm. The majority is positive for anaplastic lymphoma kinase (ALK). Initial presentation as a soft-tissue pelvic mass without nodal involvement is rare and can be easily misdiagnosed. We report a case of a 12-year-old...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elmer Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9990711/ https://www.ncbi.nlm.nih.gov/pubmed/36895288 http://dx.doi.org/10.14740/jh1081 |
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author | Lozano-Jaramillo, Diego Alberto Millan-Arreola, Esperanza Esquer-Cota, Oscar Omar Lozano-Garcia, Jesus Manuel Valenzuela-Espinoza, Miguel Alfonso |
author_facet | Lozano-Jaramillo, Diego Alberto Millan-Arreola, Esperanza Esquer-Cota, Oscar Omar Lozano-Garcia, Jesus Manuel Valenzuela-Espinoza, Miguel Alfonso |
author_sort | Lozano-Jaramillo, Diego Alberto |
collection | PubMed |
description | Anaplastic large cell lymphoma (ALCL) is children’s most common mature T-cell neoplasm. The majority is positive for anaplastic lymphoma kinase (ALK). Initial presentation as a soft-tissue pelvic mass without nodal involvement is rare and can be easily misdiagnosed. We report a case of a 12-year-old male presenting with pain and movement restriction in the right extremity. Computed tomography (CT) scan revealed a solitary pelvic mass. Initial biopsy examination concluded rhabdomyosarcoma. After developing pediatric multisystemic inflammatory syndrome due to coronavirus disease 2019 (COVID-19), central and peripheral lymph node enlargement appeared. New cervical adenopathy and pelvic mass biopsies were performed. Immunohistochemistry concluded an ALK-positive ALCL with a small-cell pattern. The patient was treated with brentuximab-based chemotherapy and eventually improved. Differential diagnosis of pelvic masses in children and adolescents must include ALCL. An inflammatory trigger may promote the appearance of a typical nodal disease, previously absent. Attention is warranted during histopathological examination to avoid diagnostic errors. |
format | Online Article Text |
id | pubmed-9990711 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elmer Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-99907112023-03-08 Soft-Tissue Anaplastic Lymphoma Kinase-Positive Anaplastic Large Cell Lymphoma in a Child Unmasked by COVID-19 Lozano-Jaramillo, Diego Alberto Millan-Arreola, Esperanza Esquer-Cota, Oscar Omar Lozano-Garcia, Jesus Manuel Valenzuela-Espinoza, Miguel Alfonso J Hematol Case Report Anaplastic large cell lymphoma (ALCL) is children’s most common mature T-cell neoplasm. The majority is positive for anaplastic lymphoma kinase (ALK). Initial presentation as a soft-tissue pelvic mass without nodal involvement is rare and can be easily misdiagnosed. We report a case of a 12-year-old male presenting with pain and movement restriction in the right extremity. Computed tomography (CT) scan revealed a solitary pelvic mass. Initial biopsy examination concluded rhabdomyosarcoma. After developing pediatric multisystemic inflammatory syndrome due to coronavirus disease 2019 (COVID-19), central and peripheral lymph node enlargement appeared. New cervical adenopathy and pelvic mass biopsies were performed. Immunohistochemistry concluded an ALK-positive ALCL with a small-cell pattern. The patient was treated with brentuximab-based chemotherapy and eventually improved. Differential diagnosis of pelvic masses in children and adolescents must include ALCL. An inflammatory trigger may promote the appearance of a typical nodal disease, previously absent. Attention is warranted during histopathological examination to avoid diagnostic errors. Elmer Press 2023-02 2023-02-25 /pmc/articles/PMC9990711/ /pubmed/36895288 http://dx.doi.org/10.14740/jh1081 Text en Copyright 2023, Lozano-Jaramillo et al. https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution Non-Commercial 4.0 International License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Lozano-Jaramillo, Diego Alberto Millan-Arreola, Esperanza Esquer-Cota, Oscar Omar Lozano-Garcia, Jesus Manuel Valenzuela-Espinoza, Miguel Alfonso Soft-Tissue Anaplastic Lymphoma Kinase-Positive Anaplastic Large Cell Lymphoma in a Child Unmasked by COVID-19 |
title | Soft-Tissue Anaplastic Lymphoma Kinase-Positive Anaplastic Large Cell Lymphoma in a Child Unmasked by COVID-19 |
title_full | Soft-Tissue Anaplastic Lymphoma Kinase-Positive Anaplastic Large Cell Lymphoma in a Child Unmasked by COVID-19 |
title_fullStr | Soft-Tissue Anaplastic Lymphoma Kinase-Positive Anaplastic Large Cell Lymphoma in a Child Unmasked by COVID-19 |
title_full_unstemmed | Soft-Tissue Anaplastic Lymphoma Kinase-Positive Anaplastic Large Cell Lymphoma in a Child Unmasked by COVID-19 |
title_short | Soft-Tissue Anaplastic Lymphoma Kinase-Positive Anaplastic Large Cell Lymphoma in a Child Unmasked by COVID-19 |
title_sort | soft-tissue anaplastic lymphoma kinase-positive anaplastic large cell lymphoma in a child unmasked by covid-19 |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9990711/ https://www.ncbi.nlm.nih.gov/pubmed/36895288 http://dx.doi.org/10.14740/jh1081 |
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